Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
about
Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of actionInhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytesBile acid receptors and nonalcoholic fatty liver diseaseHepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in miceBile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rateBile acid nuclear receptor FXR and digestive system diseasesBile acid signaling in metabolic disease and drug therapyFarnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cellsFarnesoid X receptor is essential for normal glucose homeostasisStrain background modifies phenotypes in the ATP8B1-deficient mouse.Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.Bile acid sequestrants for lipid and glucose control.FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1cNuclear receptors: mediators and modifiers of inflammation-induced cholestasis.The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell FateImpact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster.Clinical challenge in hepatologyGenome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.The farnesoid X receptor: a novel drug target?Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective.Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modificationsHuman cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptorRoles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cellsEffect of retinoids on UDP-glucuronosyltransferase 2B7 mRNA expression in Caco-2 cells.Nuclear receptors in renal diseaseFarnesoid X receptor represses hepatic human APOA gene expression.Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.Bile Acid signaling in liver metabolism and diseases.Role of gut barrier function in the pathogenesis of nonalcoholic Fatty liver disease.Effects of FXR in foam-cell formation and atherosclerosis development.Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expressionStructural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor.Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice.Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells.Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport.
P2860
Q24613405-2468ED4E-A2EE-47A4-8B5B-56854B89B155Q24648243-9721F349-954A-442D-A67E-F30BD0229AC6Q26775814-3293F251-B9DA-466D-9D8C-C8B843368A7BQ27320737-D20034A0-C20F-4F42-92D7-DA5988BE055CQ27321021-39EC5371-DD1E-4D29-8293-BDB30A98BBA6Q28085493-2B77B1D1-88B9-491B-B17B-99534E349F85Q28244875-ACB8F8E4-A014-49CB-B8B4-E4548A94F095Q28571177-71ED1DAA-A40F-4E66-AF78-08C35E8A7E5BQ28591952-9F07500A-CB10-4523-9E26-4ACF098FE596Q33529062-C1F2B40D-CDA6-441A-B0E6-A54E5773B05BQ33610738-CE6123DF-7891-4869-8580-D912D31E92C2Q33651272-24FB49D2-5DA1-48F2-B483-438024899EB9Q33741191-95E523D7-186A-4ACE-82F1-0A50F8DEB818Q33785270-18B33C1C-C5FE-477F-A285-DFC7DFF4F51DQ33859400-D400214F-594A-46B4-B18D-38C12E155384Q33905488-9A388374-8C01-4AFD-8C42-50CDCB31589CQ33938794-DDADE1B1-F3F3-46FC-8B68-313544DF5275Q34135006-54200E1E-9021-4628-9332-9BCA213F341BQ34189248-98324D88-A19E-4B02-B52D-7FCC416ABABDQ34303001-EC15FED9-6D73-4231-9062-13C865EE7296Q34343494-2478A4D0-1A8C-4BD3-B212-15A5B26E0666Q34424374-A619F0CA-9ECF-45AB-A1C8-434497AA4A31Q34620714-D62027E1-4335-4375-BB1C-8742CDCF9768Q34694229-12FFB692-7382-4BEB-94B8-15D075E21D40Q34793071-E89AB5C7-B726-4968-9930-9E56737A195AQ34955918-168C752E-18A9-4CBD-8DE7-4D13D1E38693Q35080494-F3FC7ACF-376C-4C60-853A-97303B2CC328Q35086439-3AB24190-67AA-4E87-86CA-A96C67DC5B17Q35120702-53309925-1B93-4225-AF6B-0FA9C0D0A41FQ35187047-9A4F00DF-78BC-4741-A135-06054994F64EQ35204411-1FA5F7D1-11CF-4A3C-BD91-B6ABA0201898Q35257218-8ADF77AF-344A-460E-87A5-5618E7FC5C8CQ35471233-23E6E844-DB9B-48B1-A7CF-E2196DB7C74CQ35546179-F2020E93-76F0-4050-B531-099FBB2A7A5DQ35786712-D028165C-1EBF-4587-8F79-4AFDC9B59940Q35925879-3783E5D2-AC28-490D-946D-B5DBD4BBA71EQ35931282-7E1FE603-41D0-4B87-A631-61082698074CQ35990400-4C6A6D5F-605F-4DA2-ADDA-DF9E8DE21308Q36145170-A74B6C96-46DA-4415-8778-C7093239D488Q36173599-54EAA8CA-DA4A-455A-A8F2-2FA3E17EBBA8
P2860
Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Bile acid-activated nuclear re ...... negative FXR response element.
@ast
Bile acid-activated nuclear re ...... negative FXR response element.
@en
Bile acid-activated nuclear re ...... negative FXR response element.
@nl
type
label
Bile acid-activated nuclear re ...... negative FXR response element.
@ast
Bile acid-activated nuclear re ...... negative FXR response element.
@en
Bile acid-activated nuclear re ...... negative FXR response element.
@nl
prefLabel
Bile acid-activated nuclear re ...... negative FXR response element.
@ast
Bile acid-activated nuclear re ...... negative FXR response element.
@en
Bile acid-activated nuclear re ...... negative FXR response element.
@nl
P2093
P2860
P50
P356
P1476
Bile acid-activated nuclear re ...... negative FXR response element.
@en
P2093
Audrey Sirvent
Bart Staels
Dean W Hum
Ekkehard Sturm
Folkert Kuipers
Hélène Duez
Inés Pineda Torra
Thierry Claudel
Vladimir Kosykh
P2860
P304
P356
10.1172/JCI0214505
P407
P577
2002-04-01T00:00:00Z