Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element. - Wikidata - wikimedia - TriplyDB

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

http://www.wikidata.org/entity/Q34790389

about

Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action Inhibition of acyl-coenzyme A:cholesterol acyltransferase stimulates cholesterol efflux from macrophages and stimulates farnesoid X receptor in hepatocytes Bile acid receptors and nonalcoholic fatty liver disease Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice Bile acid sequestration reduces plasma glucose levels in db/db mice by increasing its metabolic clearance rate Bile acid nuclear receptor FXR and digestive system diseases Bile acid signaling in metabolic disease and drug therapy Farnesoid X receptor, through the binding with steroidogenic factor 1-responsive element, inhibits aromatase expression in tumor Leydig cells Farnesoid X receptor is essential for normal glucose homeostasis Strain background modifies phenotypes in the ATP8B1-deficient mouse.Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration.Bile acid sequestrants for lipid and glucose control.FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats.Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c Nuclear receptors: mediators and modifiers of inflammation-induced cholestasis.The Bile Acid Nuclear Receptor FXRα Is a Critical Regulator of Mouse Germ Cell Fate Impact of dietary fat type within the context of altered cholesterol homeostasis on cholesterol and lipoprotein metabolism in the F1B hamster.Clinical challenge in hepatology Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1.Recent insights into farnesoid X receptor in non-alcoholic fatty liver disease.The farnesoid X receptor: a novel drug target?Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.Improving glycemic and cholesterol control through an integrated approach incorporating colesevelam - a clinical perspective.Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype.Studies in mice, hamsters, and rats demonstrate that repression of hepatic apoA-I expression by taurocholic acid in mice is not mediated by the farnesoid-X-receptor Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells Effect of retinoids on UDP-glucuronosyltransferase 2B7 mRNA expression in Caco-2 cells.Nuclear receptors in renal disease Farnesoid X receptor represses hepatic human APOA gene expression.Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells.Bile Acid signaling in liver metabolism and diseases.Role of gut barrier function in the pathogenesis of nonalcoholic Fatty liver disease.Effects of FXR in foam-cell formation and atherosclerosis development.Farnesoid X receptor inhibits tamoxifen-resistant MCF-7 breast cancer cell growth through downregulation of HER2 expression Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor.Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice.Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells.Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease.The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport.

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P2860

Bile acid-activated nuclear receptor FXR suppresses apolipoprotein A-I transcription via a negative FXR response element.

http://www.wikidata.org/entity/Q34790389

description

2002 nî lūn-bûn

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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի ապրիլին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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type

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Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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Bile acid-activated nuclear re ...... negative FXR response element.

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Journal of Clinical Investigation

P1476

Bile acid-activated nuclear re ...... negative FXR response element.

@en

P2093

Audrey Sirvent

http://www.w3.org/2001/XMLSchema#string

Bart Staels

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Dean W Hum

http://www.w3.org/2001/XMLSchema#string

Ekkehard Sturm

http://www.w3.org/2001/XMLSchema#string

Folkert Kuipers

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Hélène Duez

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Inés Pineda Torra

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Thierry Claudel

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Vladimir Kosykh

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P2860

Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR

Identification of a nuclear receptor for bile acids

Bile acids: natural ligands for an orphan nuclear receptor

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter

Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis

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961-971

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scholarly article

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10.1172/JCI0214505

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7

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109

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Jean-Charles Fruchart

Folkert Kuipers

Jean Dallongeville

P577

2002-04-01T00:00:00Z

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11927623

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150929

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