Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products. - Wikidata - wikimedia - TriplyDB

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

http://www.wikidata.org/entity/Q34792136

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Experimental models of hepatotoxicity related to acute liver failure Xenobiotic and Endobiotic Mediated Interactions Between the Cytochrome P450 System and the Inflammatory Response in the Liver Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential Carnosic acid protects against acetaminophen-induced hepatotoxicity by potentiating Nrf2-mediated antioxidant capacity in mice Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats Identification of novel translational urinary biomarkers for acetaminophen-induced acute liver injury using proteomic profiling in mice Predose and Postdose Blood Gene Expression Profiles Identify the Individuals Susceptible to Acetaminophen-Induced Liver Injury in Rats Attenuating Oxidative Stress by Paeonol Protected against Acetaminophen-Induced Hepatotoxicity in Mice Reactions of electrophiles with nucleophilic thiolate sites: relevance to pathophysiological mechanisms and remediation Platelets and protease-activated receptor-4 contribute to acetaminophen-induced liver injury in mice.Hepatoprotective Effect of Polyphenol-Enriched Fraction from Folium Microcos on Oxidative Stress and Apoptosis in Acetaminophen-Induced Liver Injury in Mice Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways.Principles of liver regeneration and growth homeostasis.Tolerance to acetaminophen hepatotoxicity in the mouse model of autoprotection is associated with induction of flavin-containing monooxygenase-3 (FMO3) in hepatocytes.Role of the Nalp3 inflammasome in acetaminophen-induced sterile inflammation and liver injury.Proteomic profiling in incubation medium of mouse, rat and human precision-cut liver slices for biomarker detection regarding acute drug-induced liver injury.Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration.Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.Bazhen decoction protects against acetaminophen induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice.Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.The effect of sunitinib on the plasma exposure of intravenous paracetamol and its major metabolite: paracetamol glucuronide.Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.Complement activation in acetaminophen-induced liver injury in mice.Fibrin(ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity.Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses Parkin and mitofusins reciprocally regulate mitophagy and mitochondrial spheroid formation.Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity.Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products.Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.Matrix metalloproteinase-9 in the initial injury after hepatectomy in mice.Fas receptor-deficient lpr mice are protected against acetaminophen hepatotoxicity due to higher glutathione synthesis and enhanced detoxification of oxidant stress.Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity.Quercitrin from Toona sinensis (Juss.) M.Roem. Attenuates Acetaminophen-Induced Acute Liver Toxicity in HepG2 Cells and Mice through Induction of Antioxidant Machinery and Inhibition of Inflammation.Glutathione defense mechanism in liver injury: insights from animal models.Hepatoprotective Effect of Opuntia robusta and Opuntia streptacantha Fruits against Acetaminophen-Induced Acute Liver Damage The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation Inducing and characterizing liver regeneration in mice: Reliable models, essential "readouts" and critical perspectives.

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P2860

Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

http://www.wikidata.org/entity/Q34792136

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Current issues with acetaminop ...... efficacy of natural products.

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Anup Ramachandran

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C David Williams

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Hartmut Jaeschke

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Mitchell R McGill

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P2860

How mitochondria produce reactive oxygen species

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death

Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide

The hepatic inflammatory response after acetaminophen overdose: role of neutrophils

DAMPs, PAMPs and alarmins: all we need to know about danger

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.

Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway

The role of damage associated molecular pattern molecules in acetaminophen-induced liver injury in mice.

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