Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.
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Aha1 binds to the middle domain of Hsp90, contributes to client protein activation, and stimulates the ATPase activity of the molecular chaperoneQuantitative analysis of HSP90-client interactions reveals principles of substrate recognitionMolecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysisGenetic analysis of viable Hsp90 alleles reveals a critical role in Drosophila spermatogenesisThe hsp90 chaperone complex regulates intracellular localization of the dioxin receptorMechanisms of protein-folding diseases at a glanceContribution of chaperones to STAT pathway signaling.Contribution of N- and C-terminal domains to the function of Hsp90 in Saccharomyces cerevisiae.Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 FunctionIdentification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation.The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug bindingFunctional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasivenessInduction of premature senescence by hsp90 inhibition in small cell lung cancerA transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegansThe C terminus of c-Src inhibits breast tumor cell growth by a kinase-independent mechanism.Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation.Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells.The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?The oncoprotein kinase chaperone CDC37 functions as an oncogene in mice and collaborates with both c-myc and cyclin D1 in transformation of multiple tissuesp50(Cdc37) can buffer the temperature-sensitive properties of a mutant of Hck.Chaperones in cell cycle regulation and mitogenic signal transduction: a review.Regulation of Hsp90 ATPase activity by the co-chaperone Cdc37p/p50cdc37.Maturation of steroid receptors: an example of functional cooperation among molecular chaperones and their associated proteinsCryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.HSP90 as a new therapeutic target for cancer therapy: the story unfolds.Structure of an Hsp90-Cdc37-Cdk4 complex.The 2008 Genetics Society of America Medal. Susan LindquistHSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.Proteomics: a strategy to understand the novel targets in protein misfolding and cancer therapy.Heat shock protein 90 inhibition in lung cancer.Conformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulinBiology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update.Functional specificity of co-chaperone interactions with Hsp90 client proteins.Src-mediated phosphorylation of Hsp90 in response to vascular endothelial growth factor (VEGF) is required for VEGF receptor-2 signaling to endothelial NO synthase.Targeting chaperones in transformed systems--a focus on Hsp90 and cancer.Heat-shock protein 90 inhibitors in cancer therapy: 17AAG and beyond.The 90-kDa heat shock protein stabilizes the polysomal ribonuclease 1 mRNA endonuclease to degradation by the 26S proteasome.HSP90 affects the expression of genetic variation and developmental stability in quantitative traits.
P2860
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P2860
Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@ast
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@en
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@nl
type
label
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@ast
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@en
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@nl
prefLabel
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@ast
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@en
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@nl
P2093
P2860
P356
P1476
Maturation of the tyrosine kin ...... the molecular chaperone Hsp90.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.1.109
P407
P577
1999-01-01T00:00:00Z