Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas.
about
Deep sequencing of HPV16 genomes: A new high-throughput tool for exploring the carcinogenicity and natural history of HPV16 infection.SummonChimera infers integrated viral genomes with nucleotide precision from NGS data.Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome.Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancerMethylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia.Metagenomic assay for identification of microbial pathogens in tumor tissuesTobacco exposure results in increased E6 and E7 oncogene expression, DNA damage and mutation rates in cells maintaining episomal human papillomavirus 16 genomes.Diagnosis of 25 genotypes of human papillomaviruses for their physical statuses in cervical precancerous/cancerous lesions: a comparison of E2/E6E7 ratio-based vs. multiple E1-L1/E6E7 ratio-based detection techniquesCharacterization of HPV and host genome interactions in primary head and neck cancers.Viral carcinogenesis: factors inducing DNA damage and virus integrationVirus transcript levels and cell growth rates after naturally occurring HPV16 integration events in basal cervical keratinocytes.Genetic variation of human papillomavirus type 16 in individual clinical specimens revealed by deep sequencing.Comprehensive analysis of HPV16 integration in OSCC reveals no significant impact of physical status on viral oncogene and virally disrupted human gene expression.Transcriptionally active regions are the preferred targets for chromosomal HPV integration in cervical carcinogenesis.Chromosomal copy number alterations and HPV integration in cervical precancer and invasive cancerHPVbase--a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human papillomaviruses mediated carcinomasNGS-based approach to determine the presence of HPV and their sites of integration in human cancer genome.Functional variants of human papillomavirus type 16 demonstrate host genome integration and transcriptional alterations corresponding to their unique cancer epidemiology.The role of integration in oncogenic progression of HPV-associated cancersGenome Analysis of Latin American Cervical Cancer: Frequent Activation of the PIK3CA PathwayEvidence of disrupted high-risk human papillomavirus DNA in morphologically normal cervices of older women.HPV Population Profiling in Healthy Men by Next-Generation Deep Sequencing Coupled with HPV-QUEST.Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes.Comprehensive mapping of the human papillomavirus (HPV) DNA integration sites in cervical carcinomas by HPV capture technologyDysregulation of host cellular genes targeted by human papillomavirus (HPV) integration contributes to HPV-related cervical carcinogenesis.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instabilityHPV 16 E5 oncoprotein is expressed in early stage carcinogenesis and can be a target of immunotherapy.Genomic characterization of viral integration sites in HPV-related cancers.Integration of the full-length HPV16 genome in cervical cancer and Caski and Siha cell lines and the possible ways of HPV integration.Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.HPV Integration in Head and Neck Squamous Cell Carcinomas: Cause and Consequence.Viral load and integration status of HPV58 associated with cervical lesion severity in women of Northeast China.Genomic Integration of High-Risk HPV Alters Gene Expression in Oropharyngeal Squamous Cell Carcinoma.Simultaneous detection of human papillomavirus integration and c-MYC gene amplification in cervical lesions: an emerging marker for the risk to progression.Analysis of the integration of human papillomaviruses in head and neck tumours in relation to patients' prognosis.Sites of disruption within E1 and E2 genes of HPV16 and association with cervical dysplasia.Viral-Cellular DNA Junctions as Molecular Markers for Assessing Intra-Tumor Heterogeneity in Cervical Cancer and for the Detection of Circulating Tumor DNA.Mechanistic signatures of HPV insertions in cervical carcinomas.Utility of high-throughput DNA sequencing in the study of the human papillomaviruses.HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression.
P2860
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P2860
Multiplex Identification of Human Papillomavirus 16 DNA Integration Sites in Cervical Carcinomas.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@ast
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@en
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@nl
type
label
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@ast
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@en
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@nl
prefLabel
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@ast
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@en
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@nl
P2093
P2860
P1433
P1476
Multiplex Identification of Hu ...... Sites in Cervical Carcinomas.
@en
P2093
Elisabeth Schwarz
Martina Schmitz
Matthias Dürst
Sasithorn Chotewutmontri
Stephan Wolf
Ursula Klos
P2860
P304
P356
10.1371/JOURNAL.PONE.0066693
P407
P577
2013-06-18T00:00:00Z