Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor. - Wikidata - wikimedia - TriplyDB

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.

http://www.wikidata.org/entity/Q34794256

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Bioassays for TSH Receptor Autoantibodies, from FRTL-5 Cells to TSH Receptor-LH/CG Receptor Chimeras: The Contribution of Leonard D. Kohn Review and hypothesis: does Graves' disease develop in non-human great apes?Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer Graves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies.Excessive Cytosolic DNA Fragments as a Potential Trigger of Graves' Disease: An Encrypted Message Sent by Animal Models Epitope recognition in HLA-DR3 transgenic mice immunized to TSH-R protein or peptides.Mechanisms of Autoantibody-Induced Pathology.Targeted biological therapies for Graves' disease and thyroid-associated ophthalmopathy. Focus on B-cell depletion with Rituximab Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptor The TSH receptor reveals itself.Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis.An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure A unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor.Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease.Delineating the autoimmune mechanisms in Graves' disease Autoimmune thyroid disease.Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing.Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor Distribution.The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activation Probing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational forms Thyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa.A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.Relevance of TSH-receptor antibody levels in predicting disease course in Graves' orbitopathy: comparison of the third-generation TBII assay and Mc4-TSI bioassay Evidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' disease Techniques to quantify TSH receptor antibodies.Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigens High-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies.Pathogenesis of Hyperthyroidism.Interactions between the mannose receptor and thyroid autoantigens.News and views: at long last, an animal model of Graves' orbitopathy.Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen.Antibodies to TSH-receptor in thyroid autoimmune disease interact with monoclonal antibodies whose epitopes are broadly distributed on the receptor.Residues 34-39 in the thyrotropin receptor are not the target of autoantibodies from sera of patients with Graves' disease.Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies.Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading.Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease.

P2860

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P2860

Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.

http://www.wikidata.org/entity/Q34794256

description

2002 nî lūn-bûn

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2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2002 թվականի հուլիսին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

@ast

Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

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Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

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type

label

Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

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Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

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Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

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prefLabel

Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

@ast

Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

@en

Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

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Journal of Clinical Investigation

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Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.

@en

P2093

Alan P Johnstone

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Chun-Rong Chen

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Francesco Latrofa

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Gregorio D Chazenbalk

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Pavel Pichurin

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Sandra M McLachlan

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P2860

Two-subunit structure of the human thyrotropin receptor

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Epitope recognition by diverse antibodies suggests conformational convergence in an antibody response

A prion-like shift between two conformational forms of a recombinant thyrotropin receptor A-subunit module: purification and stabilization using chemical chaperones of the form reactive with Graves' autoantibodies.

Binding domains of stimulatory and inhibitory thyrotropin (TSH) receptor autoantibodies determined with chimeric TSH-lutropin/chorionic gonadotropin receptors.

Thyroid-stimulating antibody activity between different immunoglobulin G subclasses.

Kappa/lambda immunoglobulin distribution in Graves' thyroid-stimulating antibodies. Simultaneous analysis of C lambda gene polymorphisms.

Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.

Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule

Immunoglobulins from Graves' disease patients interact with different sites on TSH receptor/LH-CG receptor chimeras than either TSH or immunoglobulins from idiopathic myxedema patients.

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209-217

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10.1172/JCI0215745

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2

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110

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2002-07-01T00:00:00Z

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12122113

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