Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.
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Bioassays for TSH Receptor Autoantibodies, from FRTL-5 Cells to TSH Receptor-LH/CG Receptor Chimeras: The Contribution of Leonard D. KohnReview and hypothesis: does Graves' disease develop in non-human great apes?Evidence for Follicle-stimulating Hormone Receptor as a Functional TrimerGraves' Disease Mechanisms: The Role of Stimulating, Blocking, and Cleavage Region TSH Receptor Antibodies.Excessive Cytosolic DNA Fragments as a Potential Trigger of Graves' Disease: An Encrypted Message Sent by Animal ModelsEpitope recognition in HLA-DR3 transgenic mice immunized to TSH-R protein or peptides.Mechanisms of Autoantibody-Induced Pathology.Targeted biological therapies for Graves' disease and thyroid-associated ophthalmopathy. Focus on B-cell depletion with RituximabMolecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.Novel information on the epitope of an inverse agonist monoclonal antibody provides insight into the structure of the TSH receptorThe TSH receptor reveals itself.Crystal structure of a TSH receptor monoclonal antibody: insight into Graves' disease pathogenesis.An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens.The thyrotropin receptor autoantigen in Graves disease is the culprit as well as the victim.Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structureA unique mouse strain that develops spontaneous, iodine-accelerated, pathogenic antibodies to the human thyrotrophin receptor.Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease.Delineating the autoimmune mechanisms in Graves' diseaseAutoimmune thyroid disease.Identification of disease-specific motifs in the antibody specificity repertoire via next-generation sequencing.Disrupted TSH Receptor Expression in Female Mouse Lung Fibroblasts Alters Subcellular IGF-1 Receptor Distribution.The thyrotropin receptor hinge region as a surrogate ligand: identification of loci contributing to the coupling of thyrotropin binding and receptor activationProbing structural variability at the N terminus of the TSH receptor with a murine monoclonal antibody that distinguishes between two receptor conformational formsThyrotropin-blocking autoantibodies and thyroid-stimulating autoantibodies: potential mechanisms involved in the pendulum swinging from hypothyroidism to hyperthyroidism or vice versa.A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.Relevance of TSH-receptor antibody levels in predicting disease course in Graves' orbitopathy: comparison of the third-generation TBII assay and Mc4-TSI bioassayEvidence that shed thyrotropin receptor A subunits drive affinity maturation of autoantibodies causing Graves' diseaseTechniques to quantify TSH receptor antibodies.Studies in mice deficient for the autoimmune regulator (Aire) and transgenic for the thyrotropin receptor reveal a role for Aire in tolerance for thyroid autoantigensHigh-level intrathymic thyrotrophin receptor expression in thyroiditis-prone mice protects against the spontaneous generation of pathogenic thyrotrophin receptor autoantibodies.Pathogenesis of Hyperthyroidism.Interactions between the mannose receptor and thyroid autoantigens.News and views: at long last, an animal model of Graves' orbitopathy.Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen.Antibodies to TSH-receptor in thyroid autoimmune disease interact with monoclonal antibodies whose epitopes are broadly distributed on the receptor.Residues 34-39 in the thyrotropin receptor are not the target of autoantibodies from sera of patients with Graves' disease.Variable Effects of Dietary Selenium in Mice That Spontaneously Develop a Spectrum of Thyroid Autoantibodies.Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease.Thyroid Autoantibodies Display both “Original Antigenic Sin” and Epitope Spreading.Evidence that factors other than particular thyrotropin receptor T cell epitopes contribute to the development of hyperthyroidism in murine Graves' disease.
P2860
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P2860
Thyroid-stimulating autoantibodies in Graves disease preferentially recognize the free A subunit, not the thyrotropin holoreceptor.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@ast
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@en
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@nl
type
label
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@ast
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@en
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@nl
prefLabel
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@ast
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@en
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@nl
P2093
P2860
P356
P1476
Thyroid-stimulating autoantibo ...... the thyrotropin holoreceptor.
@en
P2093
Alan P Johnstone
Chun-Rong Chen
Francesco Latrofa
Gregorio D Chazenbalk
Pavel Pichurin
Sandra M McLachlan
P2860
P304
P356
10.1172/JCI0215745
P407
P577
2002-07-01T00:00:00Z