Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells - Wikidata - wikimedia - TriplyDB

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

http://www.wikidata.org/entity/Q34795512

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New insights into an X-traordinary viral protein The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP Quantitative Proteomic Approach Identifies Vpr Binding Protein as Novel Host Factor Supporting Influenza A Virus Infections in Human Cells.Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Structural basis of cellular dNTP regulation by SAMHD1.SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1 MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients.Substrates and Inhibitors of SAMHD1.Structural basis of allosteric activation of sterile α motif and histidine-aspartate domain-containing protein 1 (SAMHD1) by nucleoside triphosphates.Incorporating alternative splicing and mRNA editing into the genetic analysis of complex traits.SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells.Plastic proteins and monkey blocks: how lentiviruses evolved to replicate in the presence of primate restriction factors.A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.SAMHD1 specifically restricts retroviruses through its RNase activity.Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain.Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages Differential regulatory activities of viral protein X for anti-viral efficacy of nucleos(t)ide reverse transcriptase inhibitors in monocyte-derived macrophages and activated CD4(+) T cells Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.Phosphorylation of murine SAMHD1 regulates its antiretroviral activity Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1 Low dNTP levels are necessary but may not be sufficient for lentiviral restriction by SAMHD1.Restrictive influence of SAMHD1 on Hepatitis B Virus life cycle.Deoxynucleoside triphosphate (dNTP) synthesis and destruction regulate the replication of both cell and virus genomes.Inhibition of CUL4A Neddylation causes a reversible block to SAMHD1-mediated restriction of HIV-1 SAMHD1 restricts herpes simplex virus 1 in macrophages by limiting DNA replication.The feasibility of incorporating Vpx into lentiviral gene therapy vectors.Host SAMHD1 protein promotes HIV-1 recombination in macrophages.HIV type 1 infection of plasmacytoid and myeloid dendritic cells is restricted by high levels of SAMHD1 and cannot be counteracted by Vpx.Vpx rescue of HIV-1 from the antiviral state in mature dendritic cells is independent of the intracellular deoxynucleotide concentration.SAMHD1's protein expression profile in humans.Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection.Targeting Nucleotide Biosynthesis: A Strategy for Improving the Oncolytic Potential of DNA Viruses.The SAMHD1 knockout mouse model: in vivo veritas?Increased expression of SAMHD1 in a subset of HIV-1 elite controllers.

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Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

http://www.wikidata.org/entity/Q34795512

description

2013 nî lūn-bûn

@nan

2013 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@ast

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@en

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@nl

type

label

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@ast

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@en

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@nl

prefLabel

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@ast

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@en

Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@nl

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JOURNAL.PPAT.1003481

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Host factor SAMHD1 restricts DNA viruses in non-dividing myeloid cells

@en

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Baek Kim

http://www.w3.org/2001/XMLSchema#string

Brian M Ward

http://www.w3.org/2001/XMLSchema#string

Dong-Hyun Kim

http://www.w3.org/2001/XMLSchema#string

Jessica Tate

http://www.w3.org/2001/XMLSchema#string

Joseph A Hollenbaugh

http://www.w3.org/2001/XMLSchema#string

Michele B Daly

http://www.w3.org/2001/XMLSchema#string

Natsumi Kasai

http://www.w3.org/2001/XMLSchema#string

Peter Gee

http://www.w3.org/2001/XMLSchema#string

Sarah M Amie

http://www.w3.org/2001/XMLSchema#string

Yoshio Koyanagi

http://www.w3.org/2001/XMLSchema#string

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SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection

The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

Tetramerization of SAMHD1 is required for biological activity and inhibition of HIV infection

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

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e1003481

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scholarly article

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10.1371/JOURNAL.PPAT.1003481

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6

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2013-06-27T00:00:00Z

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245029460

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23825958

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3694861

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