SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage. - Wikidata - wikimedia - TriplyDB

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

http://www.wikidata.org/entity/Q34391609

about

Regulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implications The enemy within: endogenous retroelements and autoimmune disease RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest.The mechanism of substrate-controlled allosteric regulation of SAMHD1 activated by GTP Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative SAMHD1 protects cancer cells from various nucleoside-based antimetabolites.SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors Mouse knockout models for HIV-1 restriction factors.dNTP pool modulation dynamics by SAMHD1 protein in monocyte-derived macrophages.Structural basis of cellular dNTP regulation by SAMHD1.Aicardi-Goutières syndrome and the type I interferonopathies.MicroRNA-181 contributes to downregulation of SAMHD1 expression in CD4+ T-cells derived from Sèzary syndrome patients.SAMHD1 is a biomarker for cytarabine response and a therapeutic target in acute myeloid leukemia.Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies.A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase.Del(20q) in patients with chronic lymphocytic leukemia: a therapy-related abnormality involving lymphoid or myeloid cells Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutières syndrome.A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia.Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification.The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq Impaired dNTPase activity of SAMHD1 by phosphomimetic mutation of Thr-592 The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch.Structural Insights into the High-efficiency Catalytic Mechanism of the Sterile α-Motif/Histidine-Aspartate Domain-containing Protein.Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1 Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.Patients' Preferences for Genomic Diagnostic Testing in Chronic Lymphocytic Leukaemia: A Discrete Choice Experiment Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report.Proteomic Profiling of Hematopoietic Stem/Progenitor Cells after a Whole Body Exposure of CBA/CaJ Mice to Titanium (48Ti) Ions.DNA damage repair machinery and HIV escape from innate immune sensing.Evolving understanding of the CLL genome.The genomic landscape of chronic lymphocytic leukaemia: biological and clinical implications.Single-Stranded Nucleic Acids Bind to the Tetramer Interface of SAMHD1 and Prevent Formation of the Catalytic Homotetramer.HIV suppression by host restriction factors and viral immune evasion.Deoxyribonucleotide metabolism, mutagenesis and cancer.The druggability of intracellular nucleotide-degrading enzymes.

P2860

Q26785350-1325ECA8-B29B-4A5B-968C-1F870ADD7438 Q27021785-8458B37F-7AC7-4044-846B-D0E900C55F7A Q27314893-0B6DD117-45AD-4A83-8ACC-2EFC3B13DBF0 Q27693229-D69CE032-670E-4823-AF33-6E3454085663 Q27698300-7D1E1A0A-DD60-45AE-A562-676C1A94A814 Q28087672-9E92C9F4-172B-411E-8FD3-85BB265E0EB0 Q28601451-6CEC162F-1300-41E3-BD2B-6FCEC3F4A794 Q33878949-23FCE095-912A-4F9B-9E01-F221D06151CA Q34058270-0FE9A259-E2BB-4000-BE35-6017EB541C64 Q34161853-14E2976C-93BA-4277-8279-39B4B80D0BBE Q34169187-3A217ADF-B119-4E3D-AA49-904E925A7BF0 Q34383850-ACE5C00E-BB94-4526-81D5-E9C183412EE8 Q34479620-D957AB36-92CD-4EF7-A907-38E53CB4BB8A Q34545956-38690F5E-3E3A-4983-9D3A-91DDC93F7251 Q34547626-7EEA2F08-73C3-4BFB-8627-10E0B563A7C6 Q34548815-7D44E8D9-3A96-45E2-BDD2-5136116F90C4 Q35574307-B8D5F7DC-6C39-40E6-B0E5-FD8B8D8C7DB5 Q35908496-878F7F5E-9F9E-4E32-8B42-8A1859CDF60C Q35925694-BC3116BF-7352-4286-BACC-446B95366A06 Q35984259-53159863-20EB-4D28-AAC7-040AB182E064 Q36022313-71043E9E-9203-4D7B-81E1-D351BEC8BF4B Q36243217-4ACE7A5E-C3B5-4D28-86AB-DB21C0518ADE Q36283619-53F542FE-69C7-41A3-97A8-56720D57ADD3 Q36343183-2086B6F9-310B-4044-944E-26197A510192 Q36444075-E83D470F-7414-4FE3-8047-FEFC3BED5D06 Q36455362-3258F3E5-FE0F-4447-89B8-59D7B64269D4 Q36866147-CF0CB72A-0299-49BF-A8B7-27494489C45A Q36884141-6CFE30DF-1F02-4EE4-AE6C-BE1A510FB9C2 Q37255665-2FFAE328-E5F4-4677-9252-942171C80B8C Q37410709-4B2A9A29-E82F-4436-BE2D-11202DD2391E Q37415269-78A0CC82-7191-4F6D-8AD9-EF57A85F56D8 Q37517553-2061A585-CCCA-4AF2-B2B6-05A4CF053FBD Q37566468-54EC262A-4AD5-4F9D-A00E-9B2B9413FE6E Q38209320-88B30FEA-EA6D-40EE-BC7A-321719806F0C Q38232481-4240B7E1-BAAD-4888-B287-815559671281 Q38286344-1F824045-CA39-416F-A83D-74E5F3F1A43A Q38290524-FC35922E-5617-4E32-8218-8318CEE0A105 Q38457723-A3BB3A14-182E-4878-B264-193874640FC7 Q38572102-09546B79-EA24-4112-9CF4-3B42C0C71016 Q38650970-C548C2CB-261D-4202-9232-49133E62B8F2

P2860

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage.

http://www.wikidata.org/entity/Q34391609

description

2013 nî lūn-bûn

@nan

2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@ast

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@en

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@en-gb

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@nl

type

label

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@ast

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@en

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@en-gb

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@nl

prefLabel

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@ast

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@en

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@en-gb

SAMHD1 is mutated recurrently ...... ved in response to DNA damage.

@nl

P1433

Q34391609-D5155B48-C71A-445F-A435-6E7C7C6B0A04

P1476

Q34391609-CC86B666-C1A9-4DC3-92B4-989F93769ECA

P2093

Q34391609-061F7748-800A-46E8-AC66-21B17A9BD264

Q34391609-189B1B53-6860-470D-8894-191D3674A16B

Q34391609-1DFA56DD-9D7D-42FD-8C77-1A746E0383B6

Q34391609-20F387F6-CD9C-4FD6-AC85-01D8E9A6F309

Q34391609-2282368C-9AF8-4B78-A948-C01E0AAAB9EE

Q34391609-2501ECD0-0D8F-4D99-96DB-77733BC5B084

Q34391609-30C2F200-9C1B-4DBD-9CA2-DD728703101B

Q34391609-32CBA737-12AC-4699-A2D8-8EDF26DE89DC

Q34391609-3EB0D385-E895-4A8D-B830-9E44C222DBDC

Q34391609-40262FD7-59BB-4BA1-B546-AE09685D9F7C

P2860

Q34391609-02422DB5-A9FF-44A2-9505-5842096CDA2B

Q34391609-026881C5-3A3F-4742-88E4-806E949115D0

Q34391609-02AA2393-417C-4FF6-8A0D-5E2A91A30F8B

Q34391609-0AC38FB4-A35D-4287-937F-E5E6E840F5DC

Q34391609-16129B4A-5A5E-40BF-B755-4148E448D825

Q34391609-1DAB355D-B1B4-4C4E-912B-B6A0FEB8BBA8

Q34391609-1EA342E0-CAD2-4A30-A53A-0790888FAD41

Q34391609-28328ACE-A3F5-4D3A-8B1B-7EFA5E9DA2D2

Q34391609-2D294F8F-58B8-4D49-97A3-4B30BD4FE3F8

Q34391609-2DE439B2-C50E-48D1-8A64-E47856E094A8

P304

Q34391609-315D5E70-BB77-4A5E-995F-6ED45DA0D0C5

P31

Q34391609-BD1D46C3-9CDD-4C54-949E-A94F15167A84

P356

Q34391609-21DB09C1-3086-4D4A-BDCB-EE21E42BD6D6

P407

Q34391609-D95C2411-19BD-499E-95EE-87F0794F51F5

P433

Q34391609-25BEBAB2-BBD7-408E-B14E-900A53E1FE71

P478

Q34391609-00006D63-9E0F-4EF6-AB9F-7FF509A88E8C

P50

Q34391609-4B6C36A9-C6D8-48DF-BD39-0EFD0AF04C45

Q34391609-6A117844-1989-4487-9D95-4CB905F1A411

Q34391609-91A7CD52-078C-4C0F-9EA7-512F7204212E

Q34391609-B39B2E18-D2FB-40F4-B04E-5C68399EA92A

Q34391609-B4D33B00-7951-4704-8566-C0902EB6C694

Q34391609-DE2A1BEA-C670-4C2B-B313-7C35098A67E7

Q34391609-EA47422E-1C85-4B48-9458-FFEA1DB07F5F

P577

Q34391609-65631038-99A7-4CDD-BC0A-87A0E09B4447

P5875

Q34391609-7553497E-19E0-4F4E-B4B0-8EFD07A844D3

P698

Q34391609-CECDA158-99B0-459A-B5C4-EC18DC3D37C5

P921

Q34391609-CFCF5C81-6217-400C-918D-7E72D3A9E39F

Q34391609-DE2DA66F-089E-442D-85A3-13D59DD0E62E

Q34391609-EFED3969-B333-4184-A3D5-D8BCA4411A44

P932

Q34391609-3E11A6CD-065A-4461-AF2A-90824869FD88

P356

BLOOD-2013-04-490847

P1433

P1476

SAMHD1 is mutated recurrently ...... lved in response to DNA damage

@en

P2093

Adele T Timbs

http://www.w3.org/2001/XMLSchema#string

Amalio Telenti

http://www.w3.org/2001/XMLSchema#string

Andrew Pettitt

http://www.w3.org/2001/XMLSchema#string

Anna Schuh

http://www.w3.org/2001/XMLSchema#string

David Bentley

http://www.w3.org/2001/XMLSchema#string

Dena R Cohen

http://www.w3.org/2001/XMLSchema#string

Francois Sigaux

http://www.w3.org/2001/XMLSchema#string

Glen Wright Colopy

http://www.w3.org/2001/XMLSchema#string

Helene Dreau

http://www.w3.org/2001/XMLSchema#string

Jean Gabriel Judde

http://www.w3.org/2001/XMLSchema#string

P2860

An integrated map of genetic variation from 1,092 human genomes

Identification of human homologue of mouse IFN-gamma induced protein from human dendritic cells

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein

How SAMHD1 changes our view of viral restriction

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

P304

1021-1031

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2013-04-490847

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

123

http://www.w3.org/2001/XMLSchema#string

P50

Philippe Pasero

Samantha J.L. Knight

Jonathan Maelfait

P577

2013-12-12T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

259319935

http://www.w3.org/2001/XMLSchema#string

P698

24335234

http://www.w3.org/2001/XMLSchema#string

P921

P932

3924925

http://www.w3.org/2001/XMLSchema#string