C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.
about
DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survivalNovel anti-apoptotic microRNAs 582-5p and 363 promote human glioblastoma stem cell survival via direct inhibition of caspase 3, caspase 9, and Bim.Trojan-horse nanotube on-command intracellular drug deliveryDevelopment of EGFR-targeted nanoemulsion for imaging and novel platinum therapy of ovarian cancerInterdiction of sphingolipid metabolism to improve standard cancer therapies.Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells.Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.Metronomic ceramide analogs inhibit angiogenesis in pancreatic cancer through up-regulation of caveolin-1 and thrombospondin-1 and down-regulation of cyclin D1.HDAC6 and ovarian cancer.Ultraviolet (UV) and hydrogen peroxide activate ceramide-ER stress-AMPK signaling axis to promote retinal pigment epithelium (RPE) cell apoptosis.Long intergenic non-coding RNA APOC1P1-3 inhibits apoptosis by decreasing α-tubulin acetylation in breast cancerMHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling.Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling.Pre-clinical characterization of PKC412, a multi-kinase inhibitor, against colorectal cancer cellsp53 and Ceramide as Collaborators in the Stress ResponseHistone deacetylase 6 in health and disease.A novel mechanism of ERK1/2 regulation in smooth muscle involving acetylation of the ERK1/2 scaffold IQGAP1.C6 ceramide sensitizes the anti-hepatocellular carcinoma (HCC) activity by AZD-8055, a novel mTORC1/2 dual inhibitor.Pre-clinical characterization of 4SC-202, a novel class I HDAC inhibitor, against colorectal cancer cells.Delivery systems of ceramide in targeted cancer therapy: ceramide alone or in combination with other anti-tumor agents.C6 ceramide dramatically increases vincristine sensitivity both in vivo and in vitro, involving AMP-activated protein kinase-p53 signaling.Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation.Targeting inhibitor 2 of protein phosphatase 2A as a therapeutic strategy for prostate cancer treatment.Sphingosine kinase-1 inhibition sensitizes curcumin-induced growth inhibition and apoptosis in ovarian cancer cells.Co-administration phenoxodiol with doxorubicin synergistically inhibit the activity of sphingosine kinase-1 (SphK1), a potential oncogene of osteosarcoma, to suppress osteosarcoma cell growth both in vivo and in vitro.Analysis of apoptosis methods recently used in Cancer Research and Cell Death & Disease publications.Synthesis and evaluation of xanthone derivatives as acid sphingomyelinase inhibitors: potential treatment for UV-induced skin damage.Ceramide lipid-based nanosuspension for enhanced delivery of docetaxel with synergistic antitumor efficiency.Ceramide production mediates cinobufotalin-induced growth inhibition and apoptosis in cultured hepatocellular carcinoma cells.The short chain cell-permeable ceramide (C6) restores cell apoptosis and perifosine sensitivity in cultured glioblastoma cells.
P2860
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P2860
C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@ast
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@en
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@nl
type
label
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@ast
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@en
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@nl
prefLabel
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@ast
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@en
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@nl
P2093
P2860
P356
P1476
C6-ceramide synergistically po ...... ion both in vitro and in vivo.
@en
P2093
P2860
P2888
P356
10.1038/CDDIS.2010.96
P577
2011-01-27T00:00:00Z
P5875
P6179
1012049425