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Structural insights into HDAC6 tubulin deacetylation and its selective inhibitionNatural Compound Histone Deacetylase Inhibitors (HDACi): Synergy with Inflammatory Signaling Pathway Modulators and Clinical Applications in CancerThe role of prostate tumor overexpressed 1 in cancer progressionPhosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.The role of promoter cis-element, mRNA capping, and ROS in the repression and salt-inducible expression of AtSOT12 in Arabidopsis.HDAC6 regulates IL-17 expression in T lymphocytes: implications for HDAC6-targeted therapies.AN INHIBITOR OF HISTONE DEACETYLASE 6 ACTIVITY, ACY-1215, REDUCES cAMP and CYST GROWTH IN POLYCYSTIC KIDNEY DISEASE.A seasonal switch in histone deacetylase gene expression in the hypothalamus and their capacity to modulate nuclear signaling pathways.Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.Demonstration of primary cilia and acetylated α-tubulin in fish endothelial, epithelial and fibroblast cell lines.Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma.Declined Expression of Histone Deacetylase 6 Contributes to Periodontal Ligament Stem Cell Aging.Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules.Increased histone deacetylase 6 expression serves as a favorable prognostic factor for diffuse large B-cell lymphoma.Histone deacetylase 6 inhibition counteracts the epithelial-mesenchymal transition of peritoneal mesothelial cells and prevents peritoneal fibrosis.Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.Discovery of a fluorescent probe with HDAC6 selective inhibition.Epigenetic changes in the early stage of silica-induced cell transformation.Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca2+ in knock-out mouse models of polycystic kidney disease.ARID1A-mutated ovarian cancers depend on HDAC6 activity.Suppression of FGFR3- and MYC-dependent oncogenesis by tubacin: association with HDAC6-dependent and independent activities.MiR-433 and miR-22 dysregulations induce HDAC6 overexpression and ciliary loss in cholangiocarcinoma.HDAC6 deficiency or inhibition blocks FGFR3 accumulation and improves bone growth in a model of achondroplasia.A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo.Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Histone deacetylase 6 in health and disease.
@en
type
label
Histone deacetylase 6 in health and disease.
@en
prefLabel
Histone deacetylase 6 in health and disease.
@en
P2860
P356
P1433
P1476
Histone deacetylase 6 in health and disease.
@en
P2093
Carole Seidel
Mario Dicato
P2860
P304
P356
10.2217/EPI.14.69
P577
2015-01-01T00:00:00Z