Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. - Wikidata - wikimedia - TriplyDB

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.

http://www.wikidata.org/entity/Q34800508

about

Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology Phosphorylation-mediated regulation of alternative splicing in cancer Phosphodiesterases in neurodegenerative disorders Tau promotes neurodegeneration via DRP1 mislocalization in vivo Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice TDP-43 suppresses tau expression via promoting its mRNA instability.Cyclic AMP-dependent protein kinase A regulates the alternative splicing of CaMKIIδ Two cellular protein kinases, DNA-PK and PKA, phosphorylate the adenoviral L4-33K protein and have opposite effects on L1 alternative RNA splicing Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.MicroRNAs and the Regulation of Tau Metabolism HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase.O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease.Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles Regulation of alternative splicing of tau exon 10.Extracellular Tau Paired Helical Filaments Differentially Affect Tau Pathogenic Mechanisms in Mitotic and Post-Mitotic Cells: Implications for Mechanisms of Tau Propagation in the Brain.PKA-CREB Signaling Suppresses Tau Transcription.Hsp70 alters tau function and aggregation in an isoform specific manner Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease.Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion.Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain.Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development.Role of Phosphodiesterases in Huntington's Disease.Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells.Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10.Neurotherapeutic Effects of Pueraria mirifica Extract in Early- and Late-Stage Cognitive Impaired Rats.Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: Implications for the pathogenesis of tauopathies.PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF.Presymptomatic change in microRNAs modulates Tau pathology.The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit

P2860

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P2860

Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease.

http://www.wikidata.org/entity/Q34800508

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2011 nî lūn-bûn

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2011 թուականի Մարտին հրատարակուած գիտական յօդուած

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2011 թվականի մարտին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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Cyclic AMP-dependent protein k ...... athology of Alzheimer disease.

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Cyclic AMP-dependent protein k ...... athology of Alzheimer disease.

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Cyclic AMP-dependent protein k ...... athology of Alzheimer disease.

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Cyclic AMP-dependent protein k ...... athology of Alzheimer disease.

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JBC.M110.204453

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Journal of Biological Chemistry

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Cyclic AMP-dependent protein k ...... athology of Alzheimer disease.

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Fei Ding

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Fei Liu

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Jianhua Shi

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Khalid Iqbal

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Wei Qian

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Xiaomin Yin

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Xiaosong Gu

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P2860

Transportin-SR, a nuclear import receptor for SR proteins

PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells

Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

Tau protein binds to microtubules through a flexible array of distributed weak sites

A conserved Drosophila transportin-serine/arginine-rich (SR) protein permits nuclear import of Drosophila SR protein splicing factors and their antagonist repressor splicing factor 1

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.

Transportin-SR2 mediates nuclear import of phosphorylated SR proteins

The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution

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Inge Grundke-Iqbal

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Alzheimer's disease

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