Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer. - Wikidata - wikimedia - TriplyDB

Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.

Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.

http://www.wikidata.org/entity/Q34807961

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Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.Molecular resistance fingerprint of pemetrexed and platinum in a long-term survivor of mesothelioma Ramentaceone, a Naphthoquinone Derived from Drosera sp., Induces Apoptosis by Suppressing PI3K/Akt Signaling in Breast Cancer Cells Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method.Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments.Pseudomonas aeruginosa exotoxin A reduces chemoresistance of oral squamous carcinoma cell via inhibition of heat shock proteins 70 (HSP70).Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates.Targeted therapies for soft-tissue sarcomas.Enhancement of radiation effect using beta-lapachone and underlying mechanism.Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.Effects of a novel β-lapachone derivative on Trypanosoma cruzi: Parasite death involving apoptosis, autophagy and necrosis.Synergistic effect of ionizing radiation and beta-Lapachone against RKO human colon adenocarcinoma cells.De-novo NAD+ synthesis regulates SIRT1-FOXO1 apoptotic pathway in response to NQO1 substrates in lung cancer cells.Radiation countermeasure agents: an update.PLS-Prediction and Confirmation of Hydrojuglone Glucoside as the Antitrypanosomal Constituent of Juglans Spp.Synthesis and cytotoxic evaluation of a series of 2-amino-naphthoquinones against human cancer cells.Peroxiredoxin 1 knockdown potentiates β-lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals.Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein.Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice.A novel solid dosage form of rifampicin and isoniazid with improved functionality.Understanding and predicting the potency of ROS-based enzyme inhibitors, exemplified by naphthoquinones and ubiquitin specific protease-2.Effect of new antioxidant cysteinyl-flavanol conjugates on skin cancer cells.Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles.Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions.Synthesis, Characterization, and Antileukemic Properties of Naphthoquinone Derivatives of Lawsone.Apoptotic chemotherapies.Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation.Novel Strategies for the Discovery of Plant-Derived Anticancer Agents Fluorogenic ATP Analogues for Online Monitoring of ATP Consumption: Observing Ubiquitin Activation in Real Time Temperature-sensitive gels for intratumoral delivery of β-lapachone: effect of cyclodextrins and ethanol

P2860

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P2860

Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.

http://www.wikidata.org/entity/Q34807961

description

2003 nî lūn-bûn

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2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2003 թվականի փետրվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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name

Selective killing of cancer ce ...... as a strategy against cancer.

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Selective killing of cancer ce ...... as a strategy against cancer.

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Selective killing of cancer ce ...... as a strategy against cancer.

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Selective killing of cancer ce ...... as a strategy against cancer.

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Selective killing of cancer ce ...... as a strategy against cancer.

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Proceedings of the National Academy of Sciences of the United States of America

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Selective killing of cancer ce ...... as a strategy against cancer.

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P2093

Arthur B Pardee

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Chiang J Li

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J Thomas LaMont

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Xiangao Sun

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Youzhi Li

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P2860

Surfing the p53 network

Checkpoints: controls that ensure the order of cell cycle events

The DNA damage response: putting checkpoints in perspective

Genetic instabilities in human cancers

S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid

Sibling rivalry in the E2F family

G1 events and regulation of cell proliferation

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

Defying death after DNA damage.

Complexities in the development of cyclin-dependent kinase inhibitor drugs.

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2674-2678

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scholarly article

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