An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. - Wikidata - wikimedia - TriplyDB

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

http://www.wikidata.org/entity/Q35880201

about

Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones Components of cancer metabolism and therapeutic interventions Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB DCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinoma Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells An NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancer UDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cells Phenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic target Bioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage.Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapy β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers.Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment.β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos Prodrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions.Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancer Notch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cells Mitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme.Mitochondrial peroxiredoxin III is a potential target for cancer therapy SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents.The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.Tungsten-induced carcinogenesis in human bronchial epithelial cells.Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone Novel Redox-Responsive Amphiphilic Copolymer Micelles for Drug Delivery: Synthesis and Characterization Tumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC.Targeting Antioxidant Pathways with Ferrocenylated N-Heterocyclic Carbene Supported Gold(I) Complexes in A549 Lung Cancer Cells.Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma

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An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.

http://www.wikidata.org/entity/Q35880201

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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name

An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.

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An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.

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An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.

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An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.

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An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.

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Proceedings of the National Academy of Sciences of the United States of America

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An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.

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Chin-Rang Yang

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David A Boothman

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Erik A Bey

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Jinming Gao

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John D Minna

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Kathryn E Reinicke

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Luc Girard

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Melissa S Bentle

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William G Bornmann

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Ying Dong

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P2860

Protein measurement with the Folin phenol reagent

NAD(P)H:quinone oxidoreductase 1 (NQO1, DT-diaphorase), functions and pharmacogenetics

Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death

Cancer statistics, 2006

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.

Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C-->T and 465C-->T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.

Elevated DT-diaphorase activity and messenger RNA content in human non-small cell lung carcinoma: relationship to the response of lung tumor xenografts to mitomycin Cł.

Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay.

Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer.

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11832-11837

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104

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