An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
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Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implicationNAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinonesComponents of cancer metabolism and therapeutic interventionsModulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaBDCPIP (2,6-dichlorophenolindophenol) as a genotype-directed redox chemotherapeutic targeting NQO1*2 breast carcinomaMitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cellsAn NQO1-initiated and p53-independent apoptotic pathway determines the anti-tumor effect of tanshinone IIA against non-small cell lung cancerUDP-glucuronosyltransferase 1A determinates intracellular accumulation and anti-cancer effect of β-lapachone in human colon cancer cellsPhenotypic screening reveals topoisomerase I as a breast cancer stem cell therapeutic targetBioenergetic metabolites regulate base excision repair-dependent cell death in response to DNA damage.Intratumoral delivery of beta-lapachone via polymer implants for prostate cancer therapyβ-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt PathwayTumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers.Antagonistic effects of anti-EMMPRIN antibody when combined with chemotherapy against hypovascular pancreatic cancers.Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment.β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryosProdrug strategy to achieve lyophilizable, high drug loading micelle formulations through diester derivatives of β-Lapachone.High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions.Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice.Clinical significance of NQO1 polymorphism and expression of p53, SOD2, PARP1 in limited-stage small cell lung cancerNotch/HES1-mediated PARP1 activation: a cell type-specific mechanism for tumor suppression.CDDO-imidazolide induces DNA damage, G2/M arrest and apoptosis in BRCA1-mutated breast cancer cellsMitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme.Mitochondrial peroxiredoxin III is a potential target for cancer therapySoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents.The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.A direct interaction between NQO1 and a chemotherapeutic dimeric naphthoquinone.Tungsten-induced carcinogenesis in human bronchial epithelial cells.Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cellsTargeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachoneNovel Redox-Responsive Amphiphilic Copolymer Micelles for Drug Delivery: Synthesis and CharacterizationTumor-selective use of DNA base excision repair inhibition in pancreatic cancer using the NQO1 bioactivatable drug, β-lapachone.Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC.Targeting Antioxidant Pathways with Ferrocenylated N-Heterocyclic Carbene Supported Gold(I) Complexes in A549 Lung Cancer Cells.Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosisEsterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.A novel Osmium-based compound targets the mitochondria and triggers ROS-dependent apoptosis in colon carcinoma
P2860
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P2860
An NQO1- and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@ast
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@en
type
label
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@ast
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@en
prefLabel
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@ast
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@en
P2093
P2860
P356
P1476
An NQO1- and PARP-1-mediated c ...... ancer cells by beta-lapachone.
@en
P2093
Chin-Rang Yang
David A Boothman
Erik A Bey
Jinming Gao
John D Minna
Kathryn E Reinicke
Luc Girard
Melissa S Bentle
William G Bornmann
P2860
P304
11832-11837
P356
10.1073/PNAS.0702176104
P407
P577
2007-07-03T00:00:00Z