Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. - Wikidata - wikimedia - TriplyDB

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.

http://www.wikidata.org/entity/Q34808379

about

Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes Scavenger receptor BI-mediated selective uptake is required for the remodeling of high density lipoprotein by endothelial lipase Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis.The pharmacological landscape and therapeutic potential of serine hydrolases Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase Hepatic proprotein convertases modulate HDL metabolism Vertebrate endothelial lipase: comparative studies of an ancient gene and protein in vertebrate evolution Vertebrate hepatic lipase genes and proteins: a review supported by bioinformatic studies Comparative studies of vertebrate lipoprotein lipase: a key enzyme of very low density lipoprotein metabolism Increased aortic atherosclerotic plaque development in female apolipoprotein E-null mice is associated with elevated thromboxane A2 and decreased prostacyclin production.Genomewide discovery and classification of candidate ovarian fertility genes in the mouse Endothelial lipase and reverse cholesterol transport in type 2 diabetes mellitus The associations between endothelial lipase 584C/T polymorphism and HDL-C level and coronary heart disease susceptibility: a meta-analysis.Genetic causes of high and low serum HDL-cholesterol.Liver-directed gene therapy for dyslipidemia and diabetes A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis.Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins.Association of the LIPG 584C > T polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations.Apolipoprotein A-II influences apolipoprotein E-linked cardiovascular disease risk in women with high levels of HDL cholesterol and C-reactive protein.Targeted deletion of endothelial lipase increases HDL particles with anti-inflammatory properties both in vitro and in vivo.Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism.Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics.A novel fluorogenic substrate for the measurement of endothelial lipase activity.Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells.Genetic and structure-function studies of missense mutations in human endothelial lipase Lipase maturation factor 1 is required for endothelial lipase activity.Mixed modeling and multiple imputation for unobservable genotype clusters Molecular regulation of HDL metabolism and function: implications for novel therapies.The metabolic serine hydrolases and their functions in mammalian physiology and disease.Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase.Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism.Association of endothelial lipase gene-384A/C with coronary artery disease in Han Chinese people.Population-Based Resequencing of LIPG and ZNF202 Genes in Subjects with Extreme HDL Levels Investigation of the Association Between 584C/T Polymorphism of EL Gene and Risk of Premature Coronary Artery Disease in Fars Province.Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation Endothelial lipase: its role in cardiovascular disease Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels.

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P2860

Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism.

http://www.wikidata.org/entity/Q34808379

description

2003 nî lūn-bûn

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2003年の論文

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Proceedings of the National Academy of Sciences of the United States of America

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Ali J Marian

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Christie M Ballantyne

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James D Otvos

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Ke Ma

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Lawrence Chan

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P2860

A novel endothelial-derived lipase that modulates HDL metabolism

Cloning of a unique lipase from endothelial cells extends the lipase gene family

Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile

High-density lipoprotein enhancement of anticoagulant activities of plasma protein S and activated protein C.

Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels.

Dietary fat increases high density lipoprotein (HDL) levels both by increasing the transport rates and decreasing the fractional catabolic rates of HDL cholesterol ester and apolipoprotein (Apo) A-I. Presentation of a new animal model and mechanisti

Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease.

Endothelial lipase: a new lipase on the block.

The Lipoprotein and Coronary Atherosclerosis Study (LCAS): design, methods, and baseline data of a trial of fluvastatin in patients without severe hypercholesterolemia.

Molecular physiology of reverse cholesterol transport.

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