The metabolic serine hydrolases and their functions in mammalian physiology and disease.
about
Biochemical and pharmacological characterization of human α/β-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)Therapeutic potential of monoacylglycerol lipase inhibitorsThe pharmacological landscape and therapeutic potential of serine hydrolasesLarge Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates CatalysisUnconventional endocannabinoid signaling governs sperm activation via the sex hormone progesteroneBiochemical and pharmacological characterization of the human lymphocyte antigen B-associated transcript 5 (BAT5/ABHD16A)Regulation of nausea and vomiting by cannabinoids and the endocannabinoid systemMultidimensional profiling platforms reveal metabolic dysregulation caused by organophosphorus pesticidesImplementation of a Collaborative Series of Classroom-Based Undergraduate Research Experiences Spanning Chemical Biology, Biochemistry, and Neurobiology.AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAsActivity-Based Protein Profiling of Oncogene-Driven Changes in Metabolism Reveals Broad Dysregulation of PAFAH1B2 and 1B3 in Cancer.Lactobacillus rhamnosus lowers zebrafish lipid content by changing gut microbiota and host transcription of genes involved in lipid metabolism.Activity-based protein profiling as a robust method for enzyme identification and screening in extremophilic Archaea.In vivo metabolite profiling as a means to identify uncharacterized lipase function: recent success stories within the alpha beta hydrolase domain (ABHD) enzyme family.Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish.Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity.Metabolomic strategies to map functions of metabolic pathwaysDiscovery libraries targeting the major enzyme classes: the serine hydrolases.How chemoproteomics can enable drug discovery and developmentExploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platformsConfirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probesRole of endocannabinoids and cannabinoid-1 receptors in cerebrocortical blood flow regulation.Target deconvolution techniques in modern phenotypic profiling.Target identification for small bioactive molecules: finding the needle in the haystack.Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells.Decoupled roles for the atypical, bifurcated binding pocket of the ybfF hydrolase.Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target.Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetesA high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase.Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine HydrolasesLuciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity.Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL).Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitorSubstrate-Competitive Activity-Based Profiling of Ester Prodrug Activating EnzymesDAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)
P2860
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P2860
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@ast
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@en
type
label
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@ast
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@en
prefLabel
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@ast
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@en
P2860
P356
P1433
P1476
The metabolic serine hydrolases and their functions in mammalian physiology and disease.
@en
P2093
Jonathan Z Long
P2860
P304
P356
10.1021/CR200075Y
P577
2011-06-23T00:00:00Z