Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease. - Wikidata - wikimedia - TriplyDB

Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.

Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.

http://www.wikidata.org/entity/Q34823543

about

Regulation of ROCK activity in cancer Small-molecule-induced Rho-inhibition: NSAIDs after spinal cord injury The RhoA-ROCK pathway in the regulation of T and B cell responses The atypical structure and function of newborn arterial endothelium is mediated by Rho/Rho kinase signaling Protection after stroke: cellular effectors of neurovascular unit integrity.ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium.Rho/ROCK signaling in motility and metastasis of gastric cancer Association analysis of polymorphisms in ROCK2 with cardiovascular disease in a Chinese population.Activation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation Rho kinase as a therapeutic target in cardiovascular disease.Development of second-generation small-molecule RhoA inhibitors with enhanced water solubility, tissue potency, and significant in vivo efficacy.Anthrax lethal toxin-mediated disruption of endothelial VE-cadherin is attenuated by inhibition of the Rho-associated kinase pathway Investigation of Rho-Kinase Expressions and Polymorphisms in Mantle Cell Lymphoma Patients.ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway.Darapladib, a Lipoprotein-Associated Phospholipase A2 Inhibitor, Reduces Rho Kinase Activity in Atherosclerosis Central Rho kinase inhibition restores baroreflex sensitivity and angiotensin II type 1 receptor protein imbalance in conscious rabbits with chronic heart failure.ROCK1 & 2 perform overlapping and unique roles in angiogenesis and angiosarcoma tumor progression Cigarette smoke inhibits ROCK2 activation in T cells and modulates IL-22 production Suppression of the Rho/Rho-kinase pathway and prevention of cerebral vasospasm by combination treatment with statin and fasudil after subarachnoid hemorrhage in rabbit.DL0805-2, a novel indazole derivative, relaxes angiotensin II-induced contractions of rat aortic rings by inhibiting Rho kinase and calcium fluxes.Enhanced rho-associated protein kinase activation in patients with systemic lupus erythematosus.G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation.Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion.Release of nonmuscle myosin II from the cytosolic domain of tumor necrosis factor receptor 2 is required for target gene expression.Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil.Rho-kinase: important new therapeutic target in cardiovascular diseases.Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.Rho-kinase: regulation, (dys)function, and inhibition.Lipid-lowering drug therapies and chronic obstructive pulmonary disease: lung failure or just heart failure?Rho-Associated Kinase Inhibitors Promote Microglial Uptake Via the ERK Signaling Pathway.Rho Kinases and Cardiac Remodeling.In Development-A New Paradigm for Understanding Vascular Disease.Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations.Effects of CC-chemokine receptor 5 on ROCK2 and P-MLC2 expression after focal cerebral ischaemia-reperfusion injury in rats.ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.Rho-Kinase Blockade Attenuates Podocyte Apoptosis by Inhibiting the Notch Signaling Pathway in Diabetic Nephropathy Inhibition of rho-kinase by fasudil suppresses formation and progression of experimental abdominal aortic aneurysms

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Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.

http://www.wikidata.org/entity/Q34823543

description

2011 nî lūn-bûn

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2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Rho-associated coiled-coil-for ...... clerosis and vascular disease.

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Rho-associated coiled-coil-for ...... clerosis and vascular disease.

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Rho-associated coiled-coil-forming kinases

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type

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Rho-associated coiled-coil-for ...... clerosis and vascular disease.

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Rho-associated coiled-coil-for ...... clerosis and vascular disease.

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Rho-associated coiled-coil-forming kinases

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prefLabel

Rho-associated coiled-coil-for ...... clerosis and vascular disease.

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Rho-associated coiled-coil-for ...... clerosis and vascular disease.

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Rho-associated coiled-coil-forming kinases

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J.TIPS.2010.12.006

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Trends in Pharmacological Sciences

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Rho-associated coiled-coil-for ...... clerosis and vascular disease.

@en

P2093

Christoph Gensch

http://www.w3.org/2001/XMLSchema#string

James K Liao

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Qian Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

Rocks: multifunctional kinases in cell behaviour

The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton

The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway

Rho GTPases: biochemistry and biology

The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase

Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin

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167-173

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scholarly article

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10.1016/J.TIPS.2010.12.006

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3

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32

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2011-01-16T00:00:00Z

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49762172

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21242007

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atherosclerosis

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3080120

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