Lessons from constitutively active mutants of G protein-coupled receptors.
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Loss of constitutive activity of the growth hormone secretagogue receptor in familial short statureThe chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalizationStructure of a nanobody-stabilized active state of the β(2) adrenoceptorAgonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loopUnderstanding functional residues of the cannabinoid CB1.Nanobody stabilization of G protein-coupled receptor conformational states.Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptorOverexpression of kinin B1 receptors induces hypertensive response to des-Arg9-bradykinin and susceptibility to inflammationHow genetic errors in GPCRs affect their function: Possible therapeutic strategiesExploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study.Preservation of eumelanin hair pigmentation in proopiomelanocortin-deficient mice on a nonagouti (a/a) genetic background.Identifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2pA signal transduction pathway model prototype I: From agonist to cellular endpoint.Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction.Subclinical nonautoimmune hyperthyroidism in a family segregates with a thyrotropin receptor mutation with weakly increased constitutive activity.Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes.Comparison of class A and D G protein-coupled receptors: common features in structure and activation.G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity.Melanocortin-1 receptor structure and functional regulation.Constitutively active CCR5 chemokine receptors differ in mediating HIV envelope-dependent fusion.Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.Signaling-sensitive amino acids surround the allosteric ligand binding site of the thyrotropin receptor.Mining the receptorome.Inverse agonism: more than reverting constitutively active receptor signaling.Functional relevance of naturally occurring mutations in adhesion G protein-coupled receptor ADGRD1 (GPR133).Functional Characterization of PRKAR1A Mutations Reveals a Unique Molecular Mechanism Causing Acrodysostosis but Multiple Mechanisms Causing Carney Complex.Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs.Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptorsAn intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.G protein coupled receptor structure and activationAT1 mutations and risk of atrial fibrillation based on genotypes from 71,000 individuals from the general populationConstitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.Novel insights on thyroid-stimulating hormone receptor signal transduction.The end of a myth: cloning and characterization of the ovine melatonin MT(2) receptor.Structure and dynamics of a constitutively active neurotensin receptor.Label-free optical biosensor: a tool for G protein-coupled receptors pharmacology profiling and inverse agonists identification.Selectivity of pharmacological tools: implications for use in cell physiology. A review in the theme: Cell signaling: proteins, pathways and mechanisms.Unraveling G protein-coupled receptor endocytosis pathways using real-time monitoring of agonist-promoted interaction between beta-arrestins and AP-2.Identification of a protein hydrolysate responsive G protein-coupled receptor in enterocytes.Characterization of the residues in helix 8 of the human beta1-adrenergic receptor that are involved in coupling the receptor to G proteins.
P2860
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P2860
Lessons from constitutively active mutants of G protein-coupled receptors.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Lessons from constitutively active mutants of G protein-coupled receptors.
@ast
Lessons from constitutively active mutants of G protein-coupled receptors.
@en
Lessons from constitutively active mutants of G protein-coupled receptors.
@nl
type
label
Lessons from constitutively active mutants of G protein-coupled receptors.
@ast
Lessons from constitutively active mutants of G protein-coupled receptors.
@en
Lessons from constitutively active mutants of G protein-coupled receptors.
@nl
prefLabel
Lessons from constitutively active mutants of G protein-coupled receptors.
@ast
Lessons from constitutively active mutants of G protein-coupled receptors.
@en
Lessons from constitutively active mutants of G protein-coupled receptors.
@nl
P50
P1476
Lessons from constitutively active mutants of G protein-coupled receptors.
@en
P2093
Eric Clauser
Sabine Bardin
P304
P356
10.1016/S1043-2760(02)00628-8
P577
2002-10-01T00:00:00Z