RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction
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Advances in the treatment of erectile dysfunction: what's new and upcoming?The role of phosphodiesterase-5 inhibitors in prostatic inflammation: a reviewMolecular pathophysiology of priapism: emerging targetsRho kinase proteins--pleiotropic modulators of cell survival and apoptosisY-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathwaysEfficacy of ellagic acid and sildenafil in diabetes-induced sexual dysfunctionInhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injuryCold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin.Rho kinase-mediated local cold-induced cutaneous vasoconstriction is augmented in aged human skin.Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body coolingUp-regulation of the RhoA/Rho-kinase signaling pathway in corpus cavernosum from endothelial nitric-oxide synthase (NOS), but not neuronal NOS, null mice.Treatment with a rho kinase inhibitor improves survival from graft-versus-host disease in mice after MHC-haploidentical hematopoietic cell transplantation.Inactivation of phosphorylated endothelial nitric oxide synthase (Ser-1177) by O-GlcNAc in diabetes-associated erectile dysfunctionRole of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats.Chronic treatment with Ang-(1-7) reverses abnormal reactivity in the corpus cavernosum and normalizes diabetes-induced changes in the protein levels of ACE, ACE2, ROCK1, ROCK2 and omega-hydroxylase in a rat model of type 1 diabetesRho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.RhoA/Rho-kinase and vascular diseases: what is the link?Cigarette smoking and erectile dysfunction: focus on NO bioavailability and ROS generation.Reversion of penile fibrosis: Current information and a new horizon.O-GlcNAcylation: a novel pathway contributing to the effects of endothelin in the vasculature.New approaches to the design and discovery of therapies to prevent erectile dysfunction.Endothelin-1 induces contraction of female rat internal pudendal and clitoral arteries through ET(A) receptor and rho-kinase activation.Rho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function.Arginase II deletion increases corpora cavernosa relaxation in diabetic mice.The future is today: emerging drugs for the treatment of erectile dysfunctionDesigned angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouseGas what: NO is not the only answer to sexual function.Exercise training improves the defective centrally mediated erectile responses in rats with type I diabetesMolecular mechanisms of detrusor and corporal myocyte contraction: identifying targets for pharmacotherapy of bladder and erectile dysfunctionAngiotensin II type I receptor blockade attenuates reflex cutaneous vasoconstriction in aged but not young skin.Transforming growth factor-beta 3 alters intestinal smooth muscle function: implications for gastroschisis-related intestinal dysfunction.Smooth muscle myosin expression, isoform composition, and functional activities in rat corpus cavernosum altered by the streptozotocin-induced type 1 diabetesEndothelial nitric oxide synthase keeps erection regulatory function balance in the penis.The impact of metabolic syndrome on retinal findings in patients with erectile dysfunction.Sickling cells, cyclic nucleotides, and protein kinases: the pathophysiology of urogenital disorders in sickle cell anemia.Sympathetic control of reflex cutaneous vasoconstriction in human aging.ROCKs as therapeutic targets in cardiovascular diseasesRho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges.Molecular aspects of arterial smooth muscle contraction: focus on Rho.
P2860
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P2860
RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@ast
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@en
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@nl
type
label
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@ast
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@en
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@nl
prefLabel
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@ast
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@en
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@nl
P2093
P2860
P356
P1476
RhoA/Rho-kinase suppresses end ...... ssociated erectile dysfunction
@en
P2093
Hunter C Champion
Kanchan Chitaley
Mustafa F Usta
Philip J Kadowitz
R Clinton Webb
Ronald L Lewis
Thomas M Mills
Trinity J Bivalacqua
Wayne J G Hellstrom
P2860
P304
P356
10.1073/PNAS.0400520101
P407
P50
P577
2004-06-07T00:00:00Z