Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.
about
MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationAn RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancerAlp7/TACC recruits kinesin-8-PP1 to the Ndc80 kinetochore protein for timely mitotic progression and chromosome movement.Targeting tumor suppressor networks for cancer therapeutics.Effect of NDC80 in human hepatocellular carcinomaThe Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2Diversity in genetic in vivo methods for protein-protein interaction studies: from the yeast two-hybrid system to the mammalian split-luciferase system.Nek2 is a novel regulator of B cell development and immunological response.Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy.siRNA-mediated knockdown against NUF2 suppresses pancreatic cancer proliferation in vitro and in vivo.Role of NEK2A in human cancer and its therapeutic potentials.Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Inhibition of Nek2 by small molecules affects proteasome activity.Overexpression of NDC80 is correlated with prognosis of pancreatic cancer and regulates cell proliferation.The APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisThe mitotic regulator Hec1 is a critical modulator of prostate cancer through the long non-coding RNA BX647187 in vitro.A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemiaTargeting NEK2 as a promising therapeutic approach for cancer treatment.Local depletion of DNA methylation identifies a repressive p53 regulatory region in the NEK2 promoter.Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1.An RNAi-based screen reveals PLK1, CDK1 and NDC80 as potential therapeutic targets in malignant pleural mesothelioma.NEK2 serves as a prognostic biomarker for hepatocellular carcinoma.The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival.Preclinical activity of MBM-5 in gastrointestinal cancer by inhibiting NEK2 kinase activity.Nek2 and Plk4: prognostic markers, drivers of breast tumorigenesis and drug resistance.Inhibition of Hec1 expression enhances the sensitivity of human ovarian cancer cells to paclitaxel.Centrosome clustering and chromosomal (in)stability: a matter of life and death.Cell cycle regulation by the NEK family of protein kinases.The cancer biology of whole-chromosome instability.Mitosis as an anti-cancer drug target.Targeting mitotic pathways for endocrine-related cancer therapeutics.Inhibition of Hec1 as a novel approach for treatment of primary liver cancer.Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.Proteins required for centrosome clustering in cancer cells.Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues.Up-regulation of NEK2 by microRNA-128 methylation is associated with poor prognosis in colorectal cancer.Overexpression of NIMA-related kinase 2 is associated with poor prognoses in malignant glioma.The E2F activators control multiple mitotic regulators and maintain genomic integrity through Sgo1 and BubR1.Importance of protein flexibility on molecular recognition: modeling binding mechanisms of aminopyrazine inhibitors to Nek2.
P2860
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P2860
Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Small molecule targeting the H ...... owth in culture and in animal.
@ast
Small molecule targeting the H ...... owth in culture and in animal.
@en
Small molecule targeting the H ...... owth in culture and in animal.
@nl
type
label
Small molecule targeting the H ...... owth in culture and in animal.
@ast
Small molecule targeting the H ...... owth in culture and in animal.
@en
Small molecule targeting the H ...... owth in culture and in animal.
@nl
prefLabel
Small molecule targeting the H ...... owth in culture and in animal.
@ast
Small molecule targeting the H ...... owth in culture and in animal.
@en
Small molecule targeting the H ...... owth in culture and in animal.
@nl
P2093
P2860
P1433
P1476
Small molecule targeting the H ...... rowth in culture and in animal
@en
P2093
Johnson Lau
Longen Zhou
Phang-Lang Chen
Richard Chamberlin
Wen-Hwa Lee
Xiao-Long Qiu
P2860
P304
P356
10.1158/0008-5472.CAN-08-1915
P407
P50
P577
2008-10-01T00:00:00Z