Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. - Wikidata - wikimedia - TriplyDB

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

http://www.wikidata.org/entity/Q34866369

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Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression Niemann-Pick disease type C Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP Interaction of AnxA6 with isolated and artificial lipid microdomains; importance of lipid composition and calcium content Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction Cholesterol trafficking is required for mTOR activation in endothelial cells TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+The formation and function of ER-endosome membrane contact sites Diagnostic workup and management of patients with suspected Niemann-Pick type C disease Trafficking and Functions of Bioactive Sphingolipids: Lessons from Cells and Model Membranes Molecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosis Genetic and laboratory diagnostic approach in Niemann Pick disease type C Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities Genetic dissection of a cell-autonomous neurodegenerative disorder: lessons learned from mouse models of Niemann-Pick disease type C The lysosome: from waste bag to potential therapeutic target Fingolimod for the treatment of neurological diseases-state of play and future perspectives Upstream deregulation of calcium signaling in Parkinson's disease Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Identification of dietary alanine toxicity and trafficking dysfunction in a Drosophila model of hereditary sensory and autonomic neuropathy type 1.Ca2+/H+ exchange by acidic organelles regulates cell migration in vivo.Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane A C-terminally truncated mouse Best3 splice variant targets and alters the ion balance in lysosome-endosome hybrids and the endoplasmic reticulum.Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime The GARP complex is required for cellular sphingolipid homeostasis.Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+High susceptibility to fatty liver disease in two-pore channel 2-deficient mice MLN64 mediates egress of cholesterol from endosomes to mitochondria in the absence of functional Niemann-Pick Type C1 protein Acidic calcium stores open for business: expanding the potential for intracellular Ca2+ signaling Bidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organelles Developing therapeutic approaches for metachromatic leukodystrophy Two-pore channels (TPCs): current controversies Pre-symptomatic activation of antioxidant responses and alterations in glucose and pyruvate metabolism in Niemann-Pick Type C1-deficient murine brain Alteration of gene expression profile in Niemann-Pick type C mice correlates with tissue damage and oxidative stress Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection Endo-lysosomal dysfunction in human proximal tubular epithelial cells deficient for lysosomal cystine transporter cystinosin Curcumin Mitigates the Intracellular Lipid Deposit Induced by Antipsychotics In Vitro Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity

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Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.

http://www.wikidata.org/entity/Q34866369

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2008 nî lūn-bûn

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2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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Niemann-Pick disease type C1 i ...... gulation of lysosomal calcium.

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Niemann-Pick disease type C1 i ...... gulation of lysosomal calcium.

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Niemann-Pick disease type C1 i ...... gulation of lysosomal calcium.

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Nature Medicine

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Niemann-Pick disease type C1 i ...... gulation of lysosomal calcium.

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Anthony J Morgan

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Daniel J Sillence

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David A Smith

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Edward H Schuchman

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Elena Elliot-Smith

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Emyr Lloyd-Evans

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Grant C Churchill

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Xingxuan He

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1247-1255

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scholarly article

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10.1038/NM.1876

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11

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14

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Antony Giuseppe Galione

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23416602

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1031641209

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18953351

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