P185
NAADP mobilizes calcium from acidic organelles through two-pore channelsTwo-pore channels form homo- and heterodimersHax-1 identified as a two-pore channel (TPC)-binding proteinDifferential regulation of nicotinic acid-adenine dinucleotide phosphate and cADP-ribose production by cAMP and cGMPMetabolism of the novel Ca2+-mobilizing messenger nicotinic acid-adenine dinucleotide phosphate via a 2'-specific Ca2+-dependent phosphatasePhotoaffinity labeling of high affinity nicotinic acid adenine dinucleotide phosphate (NAADP)-binding proteins in sea urchin eggTPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+Nicotinic acid adenine dinucleotide phosphate regulates skeletal muscle differentiation via action at two-pore channelsSperm express a Ca2+-regulated NAADP synthaseIdentification of a chemical probe for NAADP by virtual screeningPharmacological properties of the Ca2+-release mechanism sensitive to NAADP in the sea urchin eggEbolavirus Glycoprotein Directs Fusion through NPC1+ EndolysosomesCa2+ release from the endoplasmic reticulum of NY-ESO-1-specific T cells is modulated by the affinity of TCR and by the use of the CD8 coreceptor.Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cellsSpatial control of Ca2+ signaling by nicotinic acid adenine dinucleotide phosphate diffusion and gradientsSperm deliver a new second messenger: NAADPNAADP mobilizes Ca(2+) from reserve granules, lysosome-related organelles, in sea urchin eggsReconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+Role of NAADP and cADPR in the induction and maintenance of agonist-evoked Ca2+ spiking in mouse pancreatic acinar cellsCell-permeant NAADP: a novel chemical tool enabling the study of Ca2+ signalling in intact cellsFertilization and nicotinic acid adenine dinucleotide phosphate induce pH changes in acidic Ca(2+) stores in sea urchin eggsExpression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cellsTPC: the NAADP discovery channel?Unique inactivation properties of NAADP-sensitive Ca2+ releaseBidirectional Ca²⁺ signaling occurs between the endoplasmic reticulum and acidic organellesTwo-pore channels (TPCs): current controversiesNAADP induces Ca2+ oscillations via a two-pool mechanism by priming IP3- and cADPR-sensitive Ca2+ storesEvidence of a role for cyclic ADP-ribose in long-term synaptic depression in hippocampusPathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathwayTPC2 proteins mediate nicotinic acid adenine dinucleotide phosphate (NAADP)- and agonist-evoked contractions of smooth muscleThe ecto-enzyme CD38 is a nicotinic acid adenine dinucleotide phosphate (NAADP) synthase that couples receptor activation to Ca2+ mobilization from lysosomes in pancreatic acinar cells.Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart.High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heartAdp-ribosyl cyclase and cyclic ADP-ribose hydrolase act as a redox sensor. a primary role for cyclic ADP-ribose in hypoxic pulmonary vasoconstriction.'Click cyclic ADP-ribose': a neutral second messenger mimic.Calcium signaling via two-pore channels: local or global, that is the question.Purified TPC isoforms form NAADP receptors with distinct roles for Ca(2+) signaling and endolysosomal trafficking.TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADPTwo-pore channels for integrative Ca signaling.The calcium-mobilizing messenger nicotinic acid adenine dinucleotide phosphate participates in sperm activation by mediating the acrosome reaction
P50
Q24318546-0994A79C-3776-488A-8F01-44629236CE7EQ24337485-25261E6C-60B7-4B6B-8C21-A7EE9D2B25A0Q24339389-9958847B-FD8F-453A-8DB9-D71C76223F3BQ24530774-1D0646E4-50EF-4032-8049-59ED7E063040Q24534177-2DF08A6B-35F0-4336-981D-CCA69BF2D30BQ24600390-92AF3BD2-AD55-4DA0-8663-E0E8506D1E61Q24621022-A8305AEF-30A5-455D-8EFB-AE4C5E58B6BDQ24633669-4B4EBE41-C15E-4658-B6E1-097973CAA633Q24642734-3CB7994F-4885-47A9-98C3-6965D2A06A19Q24654132-5FC06739-46E0-4EB3-8030-412AC6C29822Q24672945-1DF3293B-D806-4B9A-964F-3E23507D32CAQ27321283-26B1747D-7F33-4343-A7AF-B00203962DEDQ27646628-E33254D6-0794-4300-A557-D69C8FFD83EBQ28138792-F71D836D-1F86-4B43-B094-33172EC907C0Q28139670-B2C5415C-DFD0-4DA6-9DCE-92D61AF18F2EQ28204936-A0510851-DFD3-439A-993E-E69E0DA06084Q28216586-4DEC7469-450D-4A1C-A80A-EA7BBEA3FF76Q28240502-6B0E48EA-608B-4EE5-94B8-20217E8F7AC5Q28249748-1C24B3FD-7A19-4C7D-9FBC-41C0FAC3DC79Q28253211-68DBCC52-34B5-4D03-AC85-6B320E3EFA1FQ28254614-0B9C74BF-F752-48FE-81D0-C11FEF3A095EQ28260464-1FB6334D-9FC5-4765-84CE-B668FEEC6FAEQ28262391-FCE9A5CC-7496-4024-AED8-C93B68DB6805Q28281723-687A9544-5839-4F0A-ADD2-2AFA1D6E245CQ28286984-12FA1A6D-1739-4D52-B3C0-2B22001FD372Q28302766-D0A1D582-5CDD-4481-AF38-7BB5D1306D85Q28366121-7CEE3805-291C-4FDE-BF81-9270CDAEFF85Q28564511-8DAB43B6-23DD-4A92-AD4B-8B5259383FEAQ28585671-E3D6173F-577E-4B03-BE8E-D376E0141F6EQ28588920-F1612E7F-DBA4-4465-9B8B-A1106DC4A529Q30497470-8D1828EA-0137-48EA-A699-69BF86E6A25FQ30834853-51239A81-D3E0-4059-9B0F-46D6F9A99A1AQ30835214-6BA005B2-D562-4224-A664-2E1BAB530A05Q31695824-6D9EC0B5-1D20-4A5C-9D79-D5DCC62CF5F3Q33719193-C1091F17-C628-4459-9C53-A4D356DC4DF5Q33727697-66E5A712-5FD7-47E4-B691-40147850F3F6Q33816664-0CFDF0AA-40D1-429B-BEBF-08A242B91126Q33840138-3C739D8B-0824-4CB1-9DD5-01167ED5F498Q33895752-4148F4B1-8845-42CE-9162-B80694C3493BQ33897722-CBA08A69-6049-44EC-A0CF-F30080DAB076
P50
description
Professor of Pharmacology and ...... macology, University of Oxford
@en
farmacoloog
@nl
أكاديمي بريطاني
@ar
name
Antony Giuseppe Galione
@ast
Antony Giuseppe Galione
@en
Antony Giuseppe Galione
@es
Antony Giuseppe Galione
@fr
Antony Giuseppe Galione
@nl
أنطوني غوسيبي غاليون
@ar
type
label
Antony Giuseppe Galione
@ast
Antony Giuseppe Galione
@en
Antony Giuseppe Galione
@es
Antony Giuseppe Galione
@fr
Antony Giuseppe Galione
@nl
أنطوني غوسيبي غاليون
@ar
altLabel
Antony Galione
@en
prefLabel
Antony Giuseppe Galione
@ast
Antony Giuseppe Galione
@en
Antony Giuseppe Galione
@es
Antony Giuseppe Galione
@fr
Antony Giuseppe Galione
@nl
أنطوني غوسيبي غاليون
@ar
P108
P1053
E-5884-2011
P106
P1153
7006334937
P184
P19
P1960
EUPxt-QAAAAJ
P2070
antony-galione-12867
P21
P213
0000 0001 3486 8471
P2798
P31
P3829
P463
P496
0000-0002-4132-7646
P569
1963-09-13T00:00:00Z