Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation - Wikidata - wikimedia - TriplyDB

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation

Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation

http://www.wikidata.org/entity/Q34871133

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Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature Disruption of the Golgi protein Otg1 gene causes defective hormone secretion and aberrant glucose homeostasis in mice.The expression and function of glucose-dependent insulinotropic polypeptide in the embryonic mouse pancreas Pancreatic beta-cell overexpression of the glucagon receptor gene results in enhanced beta-cell function and mass Mice deficient for glucagon gene-derived peptides display normoglycemia and hyperplasia of islet {alpha}-cells but not of intestinal L-cells N-glycan remodeling on glucagon receptor is an effector of nutrient sensing by the hexosamine biosynthesis pathway Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice.Animal models for small for gestational age and fetal programming of adult disease.Reducing plasma membrane sphingomyelin increases insulin sensitivity.Fertility and pregnancy-associated ß-cell proliferation in mice deficient in proglucagon-derived peptides Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms.Shared effects of genetic and intrauterine and perinatal environment on the development of metabolic syndrome Novel insight into glucagon receptor action: lessons from knockout and transgenic mouse models.Effects of genetics and in utero diet on murine pancreatic development.Nestin expression in pancreatic endocrine and exocrine cells of mice lacking glucagon signaling.Fetal adrenal demedullation lowers circulating norepinephrine and attenuates growth restriction but not reduction of endocrine cell mass in an ovine model of intrauterine growth restriction Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: a role for glucagon action in pregnancy maintenance.Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides.Investigating endogenous peptides and peptidases using peptidomics Selective expression of CYP2A13 in human pancreatic α-islet cells.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis Glucagon regulates its own synthesis by autocrine signaling.Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise Intra-islet glucagon secretion and action in the regulation of glucose homeostasis.Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia: evidence for a circulating α-cell growth factor.Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.Insulin and glucagon levels of umbilical cord blood in appropriate for gestational age - preterm infants with or without postnatal hypoglycemia Incretin action in the pancreas: potential promise, possible perils, and pathological pitfalls.Insulin signaling in alpha cells modulates glucagon secretion in vivo.Current insights and new perspectives on the roles of hyperglucagonemia in non-insulin-dependent type 2 diabetes.Oxyntomodulin increases intrinsic heart rate through the glucagon receptor.Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic alpha and beta cells in two models of alpha cell hyperplasia.Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes.Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice.Pancreas cell fate.α-cell role in β-cell generation and regeneration.

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Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation

http://www.wikidata.org/entity/Q34871133

description

2006 nî lūn-bûn

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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2006 թվականի ապրիլին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Ablation of the glucagon recep ...... let development and maturation

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Gladys Teitelman

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Lingguang Cui

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Mamdouh H Kedees

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Maureen J Charron

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Morris Nejathaim

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Patricia M Vuguin

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Richard W Gelling

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Yelena Guz

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P2860

MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

Stimulation of TM3 Leydig cell proliferation via GABA(A) receptors: a new role for testicular GABA

The proprotein convertase PC2 is involved in the maturation of prosomatostatin to somatostatin-14 but not in the somatostatin deficit in Alzheimer's disease

Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2

Endocrine pancreatic function in growth-retarded fetuses

Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells

Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter

The proprotein convertases

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10.1210/EN.2005-1410

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16627579

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4287247

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