Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist
about
Discovery and Development of Small Molecule Allosteric Modulators of Glycoprotein Hormone ReceptorsSmall GTPase regulation of GPCR anterograde traffickingRegulation of G protein-coupled receptors by allosteric ligandsPharmacological chaperoning: a primer on mechanism and pharmacologyEvidence for Follicle-stimulating Hormone Receptor as a Functional TrimerChaperoning G protein-coupled receptors: from cell biology to therapeuticsIpsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in traffickingDeducing the temporal order of cofactor function in ligand-regulated gene transcription: theory and experimental verification.Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.Misfolding Ectodomain Mutations of the Lutropin Receptor Increase Efficacy of Hormone StimulationMinireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discoveryThe iodide-transport-defect-causing mutation R124H: a δ-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter.Retinitis pigmentosa mutants provide insight into the role of the N-terminal cap in rhodopsin folding, structure, and function.Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function.Pharmacological folding chaperones act as allosteric ligands of Frizzled4.Drug repositioning can accelerate discovery of pharmacological chaperones.Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.Pharmacological Chaperones: Beyond Conformational Disorders.Intracellular Trafficking of Gonadotropin Receptors in Health and Disease.Pharmacoperones for Misfolded Gonadotropin Receptors.Pharmacological Chaperones as Potential Therapeutic Strategies for Misfolded Mutant Vasopressin Receptors.Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.A new variant in signal peptide of the human luteinizing hormone receptor (LHCGR) affects receptor biogenesis causing leydig cell hypoplasia.A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration.
P2860
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P2860
Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Rescue of expression and signa ...... binding small-molecule agonist
@ast
Rescue of expression and signa ...... binding small-molecule agonist
@en
Rescue of expression and signa ...... binding small-molecule agonist
@nl
type
label
Rescue of expression and signa ...... binding small-molecule agonist
@ast
Rescue of expression and signa ...... binding small-molecule agonist
@en
Rescue of expression and signa ...... binding small-molecule agonist
@nl
prefLabel
Rescue of expression and signa ...... binding small-molecule agonist
@ast
Rescue of expression and signa ...... binding small-molecule agonist
@en
Rescue of expression and signa ...... binding small-molecule agonist
@nl
P2093
P2860
P50
P356
P1476
Rescue of expression and signa ...... binding small-molecule agonist
@en
P2093
Adele M Whay
Chris J van Koppen
Deborah L Segaloff
Meilin Zhang
Ruud van de Lagemaat
P2860
P304
P356
10.1073/PNAS.1015723108
P407
P577
2011-04-11T00:00:00Z