Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa - Wikidata - wikimedia - TriplyDB

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

http://www.wikidata.org/entity/Q34338708

about

Folding efficiency is rate-limiting in dopamine D4 receptor biogenesis Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptors The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology G protein-coupled receptors: what a difference a 'partner' makes Rhodopsin: the functional significance of asn-linked glycosylation and other post-translational modifications Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.Using pharmacological chaperones to restore proteostasis Retinoids for treatment of retinal diseases Chaperoning G protein-coupled receptors: from cell biology to therapeutics Amino acid residues critical for endoplasmic reticulum export and trafficking of platelet-activating factor receptor Adaptation of pineal expressed teleost exo-rod opsin to non-image forming photoreception through enhanced Meta II decay.A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor.Functional characterization of rhodopsin monomers and dimers in detergents.Probing mechanisms of photoreceptor degeneration in a new mouse model of the common form of autosomal dominant retinitis pigmentosa due to P23H opsin mutations.Rescue of expression and signaling of human luteinizing hormone G protein-coupled receptor mutants with an allosterically binding small-molecule agonist G protein-coupled receptor rhodopsin.Escorts take the lead molecular chaperones as therapeutic targets Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.Molecular mechanisms of disease for mutations at Gly-90 in rhodopsin Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors Effect of rapamycin on the fate of P23H opsin associated with retinitis pigmentosa (an American Ophthalmological Society thesis).Impact of Subunit Composition on the Uptake of α-Crystallin by Lens and Retina IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin Regulation of G protein-coupled receptor export trafficking.The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology.A High-Throughput Drug Screening Strategy for Detecting Rhodopsin P23H Mutant Rescue and Degradation.Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin.Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration Selective activation of ATF6 and PERK endoplasmic reticulum stress signaling pathways prevent mutant rhodopsin accumulation 14-3-3ζ Protein regulates anterograde transport of the human κ-opioid receptor (hKOPR).Light Induces Ultrastructural Changes in Rod Outer and Inner Segments, Including Autophagy, in a Transgenic Xenopus laevis P23H Rhodopsin Model of Retinitis Pigmentosa.Unfolding the Therapeutic Potential of Chemical Chaperones for Age-related Macular Degeneration NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration Chemical and pharmacological chaperones as new therapeutic agents.Vertebrate membrane proteins: structure, function, and insights from biophysical approaches.Dysmorphic photoreceptors in a P23H mutant rhodopsin model of retinitis pigmentosa are metabolically active and capable of regenerating to reverse retinal degeneration.Search for a correlation between telomere length and severity of retinitis pigmentosa due to the dominant rhodopsin Pro23His mutation Enhancement of the surface expression of G protein-coupled receptors.Retinitis pigmentosa mutants provide insight into the role of the N-terminal cap in rhodopsin folding, structure, and function.Chaperone-like effects of cell-permeant ligands on opioid receptors.

P2860

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P2860

Pharmacological chaperone-mediated in vivo folding and stabilization of the P23H-opsin mutant associated with autosomal dominant retinitis pigmentosa

http://www.wikidata.org/entity/Q34338708

description

2003 nî lūn-bûn

@nan

2003 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2003年の論文

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2003年論文

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2003年論文

@zh-hant

2003年論文

@zh-hk

2003年論文

@zh-mo

2003年論文

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2003年论文

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name

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

@ast

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

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Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

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type

label

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

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Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

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Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

@nl

prefLabel

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

@ast

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

@en

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

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Journal of Biological Chemistry

P1476

Pharmacological chaperone-medi ...... dominant retinitis pigmentosa

@en

P2093

Li Zhu

http://www.w3.org/2001/XMLSchema#string

Shalesh Kaushal

http://www.w3.org/2001/XMLSchema#string

Syed M Noorwez

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Vladimir Kuksa

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Yoshikazu Imanishi

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P2860

Rhodopsin mutations responsible for autosomal dominant retinitis pigmentosa. Clustering of functional classes along the polypeptide chain

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

Crystal structure of rhodopsin: A G protein-coupled receptor

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

A frameshift mutation in MC4R associated with dominantly inherited human obesity

A frameshift mutation in human MC4R is associated with a dominant form of obesity

Isomerization of 11-cis-retinoids to all-trans-retinoids in vitro and in vivo.

Mechanism of rhodopsin activation as examined with ring-constrained retinal analogs and the crystal structure of the ground state protein

Synthesis and characterization of a novel retinylamine analog inhibitor of constitutively active rhodopsin mutants found in patients with autosomal dominant retinitis pigmentosa

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14442-14450

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scholarly article

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10.1074/JBC.M300087200

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16

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P478

278

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Slawomir Filipek

Krzysztof Palczewski

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2003-02-01T00:00:00Z

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12566452

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P921

molecular chaperones

P932

1361689

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