Chemo-enzymatic fluorination of unactivated organic compounds.
about
Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenaseExpanding the repertoire of biofuel alternatives through metabolic pathway evolutionEnhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.The saponins: polar isoprenoids with important and diverse biological activities.A high-throughput screen for directed evolution of the natural product sulfotransferase LipB.Oxidative aliphatic C-H fluorination with fluoride ion catalyzed by a manganese porphyrin.Enzymatic functionalization of carbon-hydrogen bonds.Cytochrome P450: taming a wild type enzymeControlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivityChemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases.Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.P450(BM3) (CYP102A1): connecting the dots.Expanding the organic toolbox: a guide to integrating biocatalysis in synthesis.Biotransformation and biocatalysis: roles and applications in the discovery of antimalarials.Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations.Drug metabolism in microorganisms.Recent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Microbial degradation of fluorinated drugs: biochemical pathways, impacts on the environment and potential applications.Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties.Late-Stage Diversification of Biologically Active Molecules via Chemoenzymatic C-H Functionalization.Biocatalytic synthesis of flavones and hydroxyl-small molecules by recombinant Escherichia coli cells expressing the cyanobacterial CYP110E1 gene.Understanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling.Mutant malonyl-CoA synthetases with altered specificity for polyketide synthase extender unit generation.Catalyst-Controlled Site-Selective Bond Activation.Regioselective hydroxylation of C(12)-C(15) fatty acids with fluorinated substituents by cytochrome P450 BM3.Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme.Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli.Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability.A dual substrate kinetic model for cytochrome P450BM3-F87G catalysis: simultaneous binding of long chain aldehydes and 4-fluorophenol.Manganese-catalyzed oxidative benzylic C-H fluorination by fluoride ions.Benzylic hydroxylation of aromatic compounds by P450 BM3
P2860
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P2860
Chemo-enzymatic fluorination of unactivated organic compounds.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Chemo-enzymatic fluorination of unactivated organic compounds.
@ast
Chemo-enzymatic fluorination of unactivated organic compounds.
@en
Chemo-enzymatic fluorination of unactivated organic compounds.
@nl
type
label
Chemo-enzymatic fluorination of unactivated organic compounds.
@ast
Chemo-enzymatic fluorination of unactivated organic compounds.
@en
Chemo-enzymatic fluorination of unactivated organic compounds.
@nl
prefLabel
Chemo-enzymatic fluorination of unactivated organic compounds.
@ast
Chemo-enzymatic fluorination of unactivated organic compounds.
@en
Chemo-enzymatic fluorination of unactivated organic compounds.
@nl
P2860
P50
P356
P1476
Chemo-enzymatic fluorination of unactivated organic compounds.
@en
P2860
P2888
P356
10.1038/NCHEMBIO.128
P577
2008-11-16T00:00:00Z