Fluorine in medicinal chemistry. - Wikidata - wikimedia - TriplyDB

Fluorine in medicinal chemistry.

Fluorine in medicinal chemistry.

http://www.wikidata.org/entity/Q35762548

about

Formation of ArF from LPdAr(F): catalytic conversion of aryl triflates to aryl fluorides Copper-free click chemistry for dynamic in vivo imaging A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex The solution structure of double helical arabino nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversion Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic Anhydrase Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists Structural basis for the enhanced stability of highly fluorinated proteins Synthesis and evaluation of fluorine-substituted phenyl acetate derivatives as ultra-short recovery sedative/hypnotic agents Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs Structure and dynamic properties of membrane proteins using NMR.Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission Enantioselective organocatalytic α-fluorination of cyclic ketones.Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative chemical redesign: mechanisms and pathways to cell death.Natural and engineered biosynthesis of fluorinated natural products.Recent advances in proteasome inhibitor discovery.The role of fluorine in medicinal chemistry.Chemo-enzymatic fluorination of unactivated organic compounds.Catalytic asymmetric intermolecular stetter reaction of heterocyclic aldehydes with nitroalkenes: backbone fluorination improves selectivity.Design and generation of highly diverse fluorinated fragment libraries and their efficient screening with improved (19) F NMR methodology.Three-component synthesis of C2F5-substituted pyrazoles from C2F5CH2NH2·HCl, NaNO2 and electron-deficient alkynes.Opposing orientations of the anti-psychotic drug trifluoperazine selected by alternate conformations of M144 in calmodulin Optimization of propafenone analogues as antimalarial leads Design of gem-difluoro-bis-tetrahydrofuran as P2 ligand for HIV-1 protease inhibitors to improve brain penetration: synthesis, X-ray studies, and biological evaluation.Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei.A beta-fluoroamine inhibitor of purine nucleoside phosphorylase A highly regio- and stereoselective synthesis of α-fluorinated imides via fluorination of chiral enamides Protein-Inhibitor Interaction Studies Using NMR Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2',3'-dideoxy-2',2'-difluoro-4'-azanucleosides Crystal structure of [bis-(2-amino-ethyl-κN)(2-{[4-(tri-fluoro-meth-yl)benzyl-idene]amino}-eth-yl)amine-κN]di-chlorido-copper(II).Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists Discovery of a Fluorinated Enigmol Analog with Enhanced in Vivo Pharmacokinetic and Anti-Tumor Properties.Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines Recent developments in methods for analysis of perfluorinated persistent pollutants Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II.(18)F-labelled cardiac PET tracers: selected probes for the molecular imaging of transporters, receptors and proteases.Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tom Trifluoromethyl ethers--synthesis and properties of an unusual substituent.

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P2860

Fluorine in medicinal chemistry.

http://www.wikidata.org/entity/Q35762548

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2004 nî lūn-bûn

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2004年論文

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2004年論文

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2004年论文

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Fluorine in medicinal chemistry.

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Fluorine in medicinal chemistry.

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Fluorine in medicinal chemistry.

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Fluorine in medicinal chemistry.

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Fluorine in medicinal chemistry.

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Fluorine in medicinal chemistry.

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Bernd Kuhn

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David Banner

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Hans-Joachim Böhm

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Klaus Müller

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Manfred Kansy

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Martin Stahl

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Stefanie Bendels

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Ulrike Obst-Sander

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P2860

van der Waals Volumes and Radii

Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II

A fluorine scan of thrombin inhibitors to map the fluorophilicity/fluorophobicity of an enzyme active site: evidence for C-F...C=O interactions

Organic Fluorine Hardly Ever Accepts Hydrogen Bonds

The pattern of fluorine substitution affects binding affinity in a small library of fluoroaromatic inhibitors for carbonic anhydrase.

Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in rabbit, mouse and human: identification of fluorine NIH shift metabolites using NMR and tandem MS.

Metabolism of fluorine-containing drugs.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

The discovery of ezetimibe: a view from outside the receptor.

New structure-activity relationships of the quinolone antibacterials using the target enzyme. The development and application of a DNA gyrase assay.

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637-643

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10.1002/CBIC.200301023

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5

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5

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2004-05-01T00:00:00Z

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15122635

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