c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
about
Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survivalA Reverse Binding Motif That Contributes to Specific Protease Inhibition by AntibodiesReduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activationMatriptase autoactivation is tightly regulated by the cellular chemical environmentsHepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for TreatmentMatriptase zymogen supports epithelial development, homeostasis and regenerationEfficient targeting of head and neck squamous cell carcinoma by systemic administration of a dual uPA and MMP-activated engineered anthrax toxin.Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesisDiversity of matriptase expression level and function in breast cancer.Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase.The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors.Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesisQuantitative analysis of gradient sensing: towards building predictive models of chemotaxis in cancer.Imaging a functional tumorigenic biomarker in the transformed epitheliumDSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarraysTargeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden.Membrane-anchored Serine Protease Matriptase Is a Trigger of Pulmonary Fibrogenesis.Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of MetMembrane-anchored proteases in endothelial cell biology.Matriptase activation connects tissue factor-dependent coagulation initiation to epithelial proteolysis and signalingType II transmembrane serine proteases as potential targets for cancer therapy.Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytesThe matriptase-prostasin proteolytic cascade in epithelial development and pathology.Mechanisms of hepatocyte growth factor activation in cancer tissues.Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation.Deregulated matriptase activity in oral squamous cell carcinoma promotes the infiltration of cancer-associated fibroblasts by paracrine activation of protease-activated receptor 2.Decreasing the ratio of matriptase/HAI‑1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer.Hepatocyte Growth Factor, a Key Tumor-Promoting Factor in the Tumor Microenvironment.The role of type II transmembrane serine protease-mediated signaling in cancer.Loss of membrane-bound serine protease inhibitor HAI-1 induces oral squamous cell carcinoma cells' invasiveness.Strong expression association between matriptase and its substrate prostasin in breast cancer.Inhibition of pro-HGF activation by SRI31215, a novel approach to block oncogenic HGF/MET signaling.Coagulation signaling to epithelia.Engineering a potent inhibitor of matriptase from the natural hepatocyte growth factor activator inhibitor type-1 (HAI-1) protein.MET signaling in keratinocytes activates EGFR and initiates squamous carcinogenesis.Regulation of matriptase and HAI-1 system, a novel therapeutic target in human endometrial cancer cells.HAI-2 stabilizes, inhibits and regulates SEA-cleavage-dependent secretory transport of matriptase.Expression of matriptase correlates with tumour progression and clinical prognosis in oral squamous cell carcinoma.
P2860
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P2860
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@ast
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@en
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@nl
type
label
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@ast
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@en
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@nl
prefLabel
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@ast
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@en
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@nl
P2093
P2860
P356
P1433
P1476
c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2010.586
P407
P577
2011-01-10T00:00:00Z
P5875
P6179
1044766707