mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.
about
Channelopathy pathogenesis in autism spectrum disordersSurface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapsesPhosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Subunit-specific regulation of N-methyl-D-aspartate (NMDA) receptor trafficking by SAP102 protein splice variantsEnvironmental Enrichment Ameliorates Behavioral Impairments Modeling Schizophrenia in Mice Lacking Metabotropic Glutamate Receptor 5Early-life lead exposure recapitulates the selective loss of parvalbumin-positive GABAergic interneurons and subcortical dopamine system hyperactivity present in schizophrenia.Infantile amnesia reflects a developmental critical period for hippocampal learning.Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapsesActivation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.Developmental origin dictates interneuron AMPA and NMDA receptor subunit composition and plasticity.Developmental heterochrony and the evolution of autistic perception, cognition and behaviorER to synapse trafficking of NMDA receptorsDevelopmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brainPostsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during developmentThe production of viral vectors designed to express large and difficult to express transgenes within neurons.Therapeutic potential of mGluR5 targeting in Alzheimer's diseaseActivity-induced synaptic delivery of the GluN2A-containing NMDA receptor is dependent on endoplasmic reticulum chaperone Bip and involved in fear memoryCasein kinase 2-mediated synaptic GluN2A up-regulation increases N-methyl-D-aspartate receptor activity and excitability of hypothalamic neurons in hypertensionDisruption of hippocampal-prefrontal cortex activity by dopamine D2R-dependent LTD of NMDAR transmission.Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortexEffects of sex and chronic neonatal nicotine treatment on Na²⁺/K⁺/Cl⁻ co-transporter 1, K⁺/Cl⁻ co-transporter 2, brain-derived neurotrophic factor, NMDA receptor subunit 2A and NMDA receptor subunit 2B mRNA expression in the postnatal rat hippocampuREST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors.Translational Concepts of mGluR5 in Synaptic Diseases of the BrainSAP102 mediates synaptic clearance of NMDA receptors.Synapse-specific and size-dependent mechanisms of spine structural plasticity accompanying synaptic weakening.Diversity in NMDA receptor composition: many regulators, many consequences.Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors.Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus.Norepinephrine enhances a discrete form of long-term depression during fear memory storage.Increasing the GluN2A/GluN2B Ratio in Neurons of the Mouse Basal and Lateral Amygdala Inhibits the Modification of an Existing Fear Memory Trace.Neurodevelopmental Expression Profile of Dimeric and Monomeric Group 1 mGluRs: Relevance to Schizophrenia Pathogenesis and Treatment.GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity.The postsynaptic organization of synapses.Synaptic plasticity of NMDA receptors: mechanisms and functional implications.Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?GluN2A versus GluN2B: twins, but quite different.Synaptic basis of social dysfunction: a focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs.Stress hormone rapidly tunes synaptic NMDA receptor through membrane dynamics and mineralocorticoid signalling.The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System.D-cycloserine in Schizophrenia: New Strategies for Improving Clinical Outcomes by Enhancing Plasticity.
P2860
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P2860
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch.
description
2011 nî lūn-bûn
@nan
2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@ast
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@en
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@nl
type
label
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@ast
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@en
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@nl
prefLabel
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@ast
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@en
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@nl
P2860
P50
P1433
P1476
mGluR5 and NMDA receptors driv ...... r NR2B to NR2A subunit switch.
@en
P2093
John T R Isaac
Jose A Matta
P2860
P304
P356
10.1016/J.NEURON.2011.02.045
P407
P577
2011-04-01T00:00:00Z