Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells - Wikidata - wikimedia - TriplyDB

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

http://www.wikidata.org/entity/Q34926558

about

MYC, Metabolism, and Cancer Mourning Dr. Alfred G. Knudson: the two-hit hypothesis, tumor suppressor genes, and the tuberous sclerosis complex ROS homeostasis and metabolism: a dangerous liason in cancer cells ROS homeostasis and metabolism: a critical liaison for cancer therapy From Krebs to clinic: glutamine metabolism to cancer therapy.Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism Tuberous sclerosis complex neuropathology requires glutamate-cysteine ligase Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference.Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.Glutaminolysis as a target for cancer therapy.2-phenylethynesulphonamide (PFT-μ) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels.Tuberous sclerosis complex: From molecular biology to novel therapeutic approaches.Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA).Myc requires RhoA/SRF to reprogram glutamine metabolism.

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Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells

http://www.wikidata.org/entity/Q34926558

description

2014 nî lūn-bûn

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2014 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2014 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

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PNAS.1417015112

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Synthetic lethality of combine ...... n in mTORC1-driven tumor cells

@en

P2093

Alfredo Csibi

http://www.w3.org/2001/XMLSchema#string

Chenggang Li

http://www.w3.org/2001/XMLSchema#string

Erik Zhang

http://www.w3.org/2001/XMLSchema#string

Gregory R Hoffman

http://www.w3.org/2001/XMLSchema#string

Jane J Yu

http://www.w3.org/2001/XMLSchema#string

Jing Li

http://www.w3.org/2001/XMLSchema#string

John Blenis

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Sun Yang

http://www.w3.org/2001/XMLSchema#string

P2860

Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

Heat shock protein 90 modulates the unfolded protein response by stabilizing IRE1alpha.

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

Signal integration in the endoplasmic reticulum unfolded protein response

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

3D tomography reveals connections between the phagophore and endoplasmic reticulum

Mitochondria supply membranes for autophagosome biogenesis during starvation.

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

Molecular mechanisms of mTOR-mediated translational control

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scholarly article

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10.1073/PNAS.1417015112

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1

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112

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2014-12-18T00:00:00Z

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269768349

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25524627

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4291663

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