An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.
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TopBP1 Governs Hematopoietic Stem/Progenitor Cells Survival in Zebrafish Definitive HematopoiesisActivation of the ATR kinase by the RPA-binding protein ETAA1Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firingThe fork and the kinase: a DNA replication tale from a CHK1 perspective.RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay.Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling.RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response.Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancer in vivo.The essential kinase ATR: ensuring faithful duplication of a challenging genome.Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion.Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR Signaling.Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo.DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line.The ATR-Activation Domain of TopBP1 Is Required for the Suppression of Origin Firing during the S Phase
P2860
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P2860
An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.
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2013 nî lūn-bûn
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2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
An essential function for the ...... pment and cellular senescence.
@ast
An essential function for the ...... pment and cellular senescence.
@en
An essential function for the ATR-activation-domain
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type
label
An essential function for the ...... pment and cellular senescence.
@ast
An essential function for the ...... pment and cellular senescence.
@en
An essential function for the ATR-activation-domain
@nl
prefLabel
An essential function for the ...... pment and cellular senescence.
@ast
An essential function for the ...... pment and cellular senescence.
@en
An essential function for the ATR-activation-domain
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P2093
P2860
P50
P1433
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An essential function for the ...... opment and cellular senescence
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P2093
Anja Krueger
Christopher Bruhn
WooKee Min
Zhao-Qi Wang
P2860
P304
P356
10.1371/JOURNAL.PGEN.1003702
P577
2013-08-08T00:00:00Z