Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice. - Wikidata - wikimedia - TriplyDB

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.

http://www.wikidata.org/entity/Q34948525

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Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes Development, growth and maintenance of β-cell mass: models are also part of the story Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction Control of cell identity in pancreas development and regeneration Modelling age-related metabolic disorders in the mouse β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes.Natural history of β-cell adaptation and failure in type 2 diabetes mRNA expression analysis of cell cycle genes in islets of pregnant mice Islet biology, the CDKN2A/B locus and type 2 diabetes risk.Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy.Ongoing beta-cell turnover in adult nonhuman primates is not adaptively increased in streptozotocin-induced diabetes Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue.Glucolipotoxicity of the pancreatic beta cell.Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents Neuropeptide Y expression marks partially differentiated β cells in mice and humans Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects.Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice microRNA-141 regulates BMI1 expression and induces senescence in human diploid fibroblasts.Glucose and aging control the quiescence period that follows pancreatic beta cell replication Age-related impairment of pancreatic Beta-cell function: pathophysiological and cellular mechanisms.Activated FoxM1 attenuates streptozotocin-mediated β-cell death.Abnormal infant islet morphology precedes insulin resistance in PCOS-like monkeys Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes.Pancreatic beta-cells: from generation to regeneration.You are what you eat, or are you? The challenges of translating high-fat-fed rodents to human obesity and diabetes.The effect of biological age on the metabolic responsiveness of mice fed a high-fat diet.The Polycomb protein, Bmi1, regulates insulin sensitivity In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming.Stimulating β-cell regeneration by combining a GPR119 agonist with a DPP-IV inhibitor.Aging induces a distinct gene expression program in mouse islets.Enhancing pancreatic Beta-cell regeneration in vivo with pioglitazone and alogliptin.βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice.Altered pancreatic growth and insulin secretion in WSB/EiJ mice.A systems view of epigenetic networks regulating pancreas development and β-cell function

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P2860

Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice.

http://www.wikidata.org/entity/Q34948525

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Age-dependent decline in beta- ...... eta-cell regeneration in mice.

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Anil Bhushan

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Sangeeta Dhawan

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Shuen-Ing Tschen

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Tatyana Gurlo

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P2860

Bmi1, stem cells, and senescence regulation

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

p16INK4a induces an age-dependent decline in islet regenerative potential

Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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