The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process - Wikidata - wikimedia - TriplyDB

The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process

The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process

http://www.wikidata.org/entity/Q34972267

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The T-box gene family: emerging roles in development, stem cells and cancer Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium The role of T‑box genes in the tumorigenesis and progression of cancer (Review)TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.Coordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex.The anti-proliferative function of the TGF-β1 signaling pathway involves the repression of the oncogenic TBX2 by its homologue TBX3 The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinases A novel role for the T-box transcription factor Tbx1 as a negative regulator of tumor cell growth in mice.The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis.Low expression of TBX4 predicts poor prognosis in patients with stage II pancreatic ductal adenocarcinoma.The ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb development NF-κB Mediates the Expression of TBX15 in Cancer Cells.The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells.The transcriptional regulator TBX3 promotes progression from non-invasive to invasive breast cancer TBX2 expression is regulated by PAX3 in the melanocyte lineage The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitor Regulation of the T-box transcription factor Tbx3 by the tumour suppressor microRNA-206 in breast cancer.The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow.TBX2 represses PTEN in rhabdomyosarcoma and skeletal muscle.Oncogenic B-RAF(V600E) signaling induces the T-Box3 transcriptional repressor to repress E-cadherin and enhance melanoma cell invasion.A novel role for the anti-senescence factor TBX2 in DNA repair and cisplatin resistance The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathway The T-box transcription factor, TBX3, is sufficient to promote melanoma formation and invasion.The T-box transcription factor 3 is a promising biomarker and a key regulator of the oncogenic phenotype of a diverse range of sarcoma subtypes Regulation of organogenesis and stem cell properties by T-box transcription factors.Novel antiapoptotic effect of TBX15: overexpression of TBX15 reduces apoptosis in cancer cells.Targeting protein kinase-b3 (akt3) signaling in melanoma.PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression.T-box 3 overexpression is associated with poor prognosis of non-small cell lung cancer Diverse functional networks of Tbx3 in development and disease TBX2 expression is associated with platinum-sensitivity of ovarian serous carcinoma.Expression level of TBX3 gene in renal carcinoma and its clinical significance.

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The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic Process

http://www.wikidata.org/entity/Q34972267

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2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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The Highly Homologous T-Box Tr ...... Roles in the Oncogenic Process

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The Highly Homologous T-Box Tr ...... Roles in the Oncogenic Process

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The Highly Homologous T-Box Tr ...... Roles in the Oncogenic Process

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The Highly Homologous T-Box Tr ...... Roles in the Oncogenic Process

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Emily Davis

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Sharon Prince

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P2860

A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome

TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence

Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation

Mitf regulation of Dia1 controls melanoma proliferation and invasiveness

Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients

TBX3 and its isoform TBX3+2a are functionally distinctive in inhibition of senescence and are overexpressed in a subset of breast cancer cell lines

Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development

Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway

Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome

Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence

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