A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome
about
Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutationTbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiationThe T-box gene family: emerging roles in development, stem cells and cancerThe T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiatorMouse TBX3 mutants suggest novel molecular mechanisms for Ulnar-mammary syndromeT-box 3 is expressed in the adult mouse hypothalamus and medullaDifferential expression of Meis2, Mab21l2 and Tbx3 during limb development associated with diversification of limb morphology in mammalsThe level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cupCoordinated control of senescence by lncRNA and a novel T-box3 co-repressor complex.T-box 3 negatively regulates osteoblast differentiation by inhibiting expression of osterix and runx2TBX3 over-expression causes mammary gland hyperplasia and increases mammary stem-like cells in an inducible transgenic mouse model.Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferation.Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma.Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2-WNT Signaling Axis.The Highly Homologous T-Box Transcription Factors, TBX2 and TBX3, Have Distinct Roles in the Oncogenic ProcessTBX3 regulates splicing in vivo: a novel molecular mechanism for Ulnar-mammary syndrome.A pathway for the control of anoikis sensitivity by E-cadherin and epithelial-to-mesenchymal transition.Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegansThe ulnar-mammary syndrome gene, Tbx3, is a direct target of the retinoic acid signaling pathway, which regulates its expression during mouse limb developmentTBX3 promotes human embryonic stem cell proliferation and neuroepithelial differentiation in a differentiation stage-dependent mannerT-box factors determine cardiac design.The T-box transcription factor TBX3 drives proliferation by direct repression of the p21(WAF1) cyclin-dependent kinase inhibitorThe T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancerThe role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects.The oncogenic TBX3 is a downstream target and mediator of the TGF-β1 signaling pathwayLoss of Tbx2 delays optic vesicle invagination leading to small optic cups.omb and circumstance.Alternative splicing of T-box transcription factor genes.Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.Reduced activity and cytoplasmic localization of Runx2 is observed in C3h10t1/2 cells overexpressing Tbx3.PMA-induced up-regulation of TBX3 is mediated by AP-1 and contributes to breast cancer cell migration.The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVsUV-mediated regulation of the anti-senescence factor Tbx2.Ectopic Tbx2 expression results in polyploidy and cisplatin resistance.Putative Breast Cancer Driver Mutations in TBX3 Cause Impaired Transcriptional Repression.Diverse functional networks of Tbx3 in development and diseaseDNA Methylation Changes in Tbx3 in a Mouse Model Exposed to Polybrominated Diphenyl Ethers.Functional characterization of TBR1 variants in neurodevelopmental disorderNovel HDAC5-interacting motifs of Tbx3 are essential for the suppression of E-cadherin expression and for the promotion of metastasis in hepatocellular carcinoma
P2860
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P2860
A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@ast
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en-gb
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@nl
type
label
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@ast
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en-gb
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@nl
prefLabel
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@ast
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en-gb
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@nl
P2093
P3181
P356
P1476
A dominant repression domain i ...... t cause ulnar-mammary syndrome
@en
P2093
P304
P3181
P356
10.1093/HMG/10.21.2403
P407
P577
2001-10-01T00:00:00Z