Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies
about
A global approach to HIV-1 vaccine developmentVirological features associated with the development of broadly neutralizing antibodies to HIV-1Co-evolution of a broadly neutralizing HIV-1 antibody and founder virusViral Escape from Neutralizing Antibodies in Early Subtype A HIV-1 Infection Drives an Increase in Autologous Neutralization BreadthHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Boosting of HIV-1 neutralizing antibody responses by a distally related retroviral envelope protein.HIV vaccine trial exploits a dual and central role for innate immunity.B-cell-lineage immunogen design in vaccine development with HIV-1 as a case studyEnvelope variants circulating as initial neutralization breadth developed in two HIV-infected subjects stimulate multiclade neutralizing antibodies in rabbits.Comparison of neutralizing antibody responses elicited from highly diverse polyvalent heterotrimeric HIV-1 gp140 cocktail immunogens versus a monovalent counterpart in rhesus macaquesMultimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNAHIV-1 envelope glycoprotein resistance to monoclonal antibody 2G12 is subject-specific and context-dependent in macaques and humans.Multimodality vaccination against clade C SHIV: partial protection against mucosal challenges with a heterologous tier 2 virus.Strategies to guide the antibody affinity maturation processDiverse antibody genetic and recognition properties revealed following HIV-1 envelope glycoprotein immunization.Competitive exclusion by autologous antibodies can prevent broad HIV-1 antibodies from arising.Cross-reactive broadly neutralizing antibodies: timing is everything.Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.Diversification in the HIV-1 Envelope Hyper-variable Domains V2, V4, and V5 and Higher Probability of Transmitted/Founder Envelope Glycosylation Favor the Development of Heterologous Neutralization BreadthLongitudinal Antigenic Sequences and Sites from Intra-Host Evolution (LASSIE) Identifies Immune-Selected HIV Variants.Motif-optimized subtype A HIV envelope-based DNA vaccines rapidly elicit neutralizing antibodies when delivered sequentially.Optimal Sequential Immunization Can Focus Antibody Responses against Diversity Loss and Distraction.Pre-existing neutralizing antibody mitigates B cell dysregulation and enhances the Env-specific antibody response in SHIV-infected rhesus macaquesNeutralizing antibodies to HIV-1 induced by immunization.Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides.HIV-1 escapes from N332-directed antibody neutralization in an elite neutralizer by envelope glycoprotein elongation and introduction of unusual disulfide bonds.Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaquesNeutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaquesImprovement of antibody responses by HIV envelope DNA and protein co-immunization.Natural infection as a blueprint for rational HIV vaccine design.Prospects for an HIV vaccine: leading B cells down the right path.Neutralizing antibodies and control of HIV: moves and countermoves.Conserved immunogens in prime-boost strategies for the next-generation HIV-1 vaccines.Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice.Development of an anti-HIV vaccine eliciting broadly neutralizing antibodies.How germinal centers evolve broadly neutralizing antibodies: the breadth of the follicular helper T cell response.Glycosylation profiling to evaluate glycoprotein immunogens against HIV-1.Mammalian cell surface display for monoclonal antibody-based FACS selection of viral envelope proteins.Anti-RAINBOW dye-specific antibodies as universal tools for the visualization of prestained protein molecular weight markers in Western blot analysis.
P2860
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P2860
Sequential immunization with a subtype B HIV-1 envelope quasispecies partially mimics the in vivo development of neutralizing antibodies
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Sequential immunization with a ...... ent of neutralizing antibodies
@ast
Sequential immunization with a ...... ent of neutralizing antibodies
@en
Sequential immunization with a ...... ent of neutralizing antibodies
@nl
type
label
Sequential immunization with a ...... ent of neutralizing antibodies
@ast
Sequential immunization with a ...... ent of neutralizing antibodies
@en
Sequential immunization with a ...... ent of neutralizing antibodies
@nl
prefLabel
Sequential immunization with a ...... ent of neutralizing antibodies
@ast
Sequential immunization with a ...... ent of neutralizing antibodies
@en
Sequential immunization with a ...... ent of neutralizing antibodies
@nl
P2093
P2860
P356
P1433
P1476
Sequential immunization with a ...... ent of neutralizing antibodies
@en
P2093
Delphine C Malherbe
Indresh Srivastava
Jason T Schuman
Jean O'Malley
Leonidas Stamatatos
Lynda Misher
Motomi Mori
Nicole A Doria-Rose
Susan Barnett
Travis Beckett
P2860
P304
P356
10.1128/JVI.02419-10
P407
P577
2011-03-23T00:00:00Z