Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.
about
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesMyc suppression of Nfkb2 accelerates lymphomagenesis.Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignanciesSKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epitheliumGP130 activation induces myeloma and collaborates with MYC.Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms.Cks1 promotion of S phase entry and proliferation is independent of p27Kip1 suppressionCks1 enhances transcription efficiency at the GAL1 locus by linking the Paf1 complex to the 19S proteasomeSkp2 deletion unmasks a p27 safeguard that blocks tumorigenesis in the absence of pRb and p53 tumor suppressors.Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.Skp2 knockout reduces cell proliferation and mouse body size: and prevents cancer?Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers.Dysregulated expression of SKP2 and its role in hematological malignancies.Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro.Short hairpin RNA-mediated down-regulation of CENP-A attenuates the aggressive phenotype of lung adenocarcinoma cells.Cks1 is a critical regulator of hematopoietic stem cell quiescence and cycling, operating upstream of Cdk inhibitors.
P2860
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P2860
Skp2 directs Myc-mediated suppression of p27Kip1 yet has modest effects on Myc-driven lymphomagenesis.
description
2010 nî lūn-bûn
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2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
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name
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@ast
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@en
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@nl
type
label
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@ast
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@en
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@nl
prefLabel
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@ast
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@en
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@nl
P2093
P2860
P1476
Skp2 directs Myc-mediated supp ...... on Myc-driven lymphomagenesis.
@en
P2093
Alexander Hoellein
Christian Peschel
Jennifer B Old
John L Cleveland
Jonas A Nilsson
Keiichi I Nakayama
Lisa Nilsson
Steffi Graf
Susanne Kratzat
Ulrich B Keller
P2860
P304
P356
10.1158/1541-7786.MCR-09-0232
P577
2010-03-02T00:00:00Z