Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. - Wikidata - wikimedia - TriplyDB

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

http://www.wikidata.org/entity/Q34999834

about

Role of Ikaros in T-cell acute lymphoblastic leukemia A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.Genome-wide transcriptional analysis of T cell activation reveals differential gene expression associated with psoriasis.Ewing's sarcoma precursors are highly enriched in embryonic osteochondrogenic progenitors Illegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.The role of Notch receptors in transcriptional regulation Genetic Analysis of T Cell Lymphomas in Carbon Ion-Irradiated Mice Reveals Frequent Interstitial Chromosome Deletions: Implications for Second Cancer Induction in Normal Tissues during Carbon Ion Radiotherapy Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.An activating intragenic deletion in NOTCH1 in human T-ALL.Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.Transcriptional regulation of the Ikzf1 locus.Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus.Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises.Wnt signaling in leukemias and myeloma: T-cell factors are in control.Ikaros fingers on lymphocyte differentiation.The molecular pathogenesis of chronic lymphocytic leukaemia.High mobility group A1 protein acts as a new target of Notch1 signaling and regulates cell proliferation in T leukemia cells.Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.A novel TRB@/NOTCH1 fusion gene in T-cell lymphoblastic lymphoma with t(7;9)(q34;q34).Cutting Edge: Codeletion of the Ras GTPase-Activating Proteins (RasGAPs) Neurofibromin 1 and p120 RasGAP in T Cells Results in the Development of T Cell Acute Lymphoblastic Leukemia.Ikaros: master of hematopoiesis, agent of leukemia.Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia.A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.Effect of Notch and PARP Pathways' Inhibition in Leukemic Cells.

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Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL.

http://www.wikidata.org/entity/Q34999834

description

2010 nî lūn-bûn

@nan

2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

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Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

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Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

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type

label

Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

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Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

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Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

@nl

prefLabel

Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

@ast

Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

@en

Oncogenic activation of the No ...... ter in Ikaros-deficient T-ALL.

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Alejandra Macias-Garcia

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Anne-Solen Geimer Le Lay

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Attila Oravecz

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Bernard Jost

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Jacques Ghysdael

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Jon C Aster

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Jérôme Mastio

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Philippe Kastner

http://www.w3.org/2001/XMLSchema#string

Stéphanie Le Gras

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Susan Chan

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P2860

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

Transcription elongation factors repress transcription initiation from cryptic sites.

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription.

Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation.

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

Signalling downstream of activated mammalian Notch

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

TEL-JAK2 transgenic mice develop T-cell leukemia.

A clustering approach for identification of enriched domains from histone modification ChIP-Seq data.

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