Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
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Targeting leukemia stem cells: which pathways drive self-renewal activity in T-cell acute lymphoblastic leukemia?Targeting Notch to overcome radiation resistanceThe relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemiaNOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitroIllegitimate V(D)J recombination-mediated deletions in Notch1 and Bcl11b are not sufficient for extensive clonal expansion and show minimal age or sex bias in frequency or junctional processing.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic miceLMO2 induces T-cell leukemia with epigenetic deregulation of CD4SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsLeukemia stem cells in T-ALL require active Hif1α and Wnt signalingTrib2 Suppresses Tumor Initiation in Notch-Driven T-ALL.Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemiaDivergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cellsStacking the DEK: from chromatin topology to cancer stem cells.Intracellular Signaling Pathways Involved in Childhood Acute Lymphoblastic Leukemia; Molecular TargetsLmo2 induces hematopoietic stem cell-like features in T-cell progenitor cells prior to leukemiaThe NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.The Notch signaling pathway as a mediator of tumor survivalEffects of interleukin-18 on natural killer cells: costimulation of activation through Fc receptors for immunoglobulin.NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways.c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells.Stem cells in gastrointestinal cancers: The road less travelled.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells.MicroRNA-34 dysregulation in gastric cancer and gastric cancer stem cell.Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency.Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.GSI promotes vincristine-induced apoptosis by enhancing multi-polar spindle formation.Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength.Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia.RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts.Hhex regulates Kit to promote radioresistance of self-renewing thymocytes in Lmo2-transgenic mice.
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P2860
Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.
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2011 nî lūn-bûn
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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
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2011年论文
@wuu
name
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@ast
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@en
type
label
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@ast
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@en
prefLabel
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@ast
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@en
P2093
P2860
P1433
P1476
Notch1 inhibition targets the ...... al1/Lmo2 mouse model of T-ALL.
@en
P2093
Jessica Tatarek
Jon C Aster
Kathleen Cullion
Michelle A Kelliher
Rachel Gerstein
Todd Ashworth
P2860
P304
P356
10.1182/BLOOD-2010-08-300343
P407
P577
2011-06-13T00:00:00Z