Targeting a cryptic allosteric site for selective inhibition of the oncogenic protein tyrosine phosphatase Shp2
about
Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug DiscoveryRational design of allosteric-inhibition sites in classical protein tyrosine phosphatases.Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.Direct Chemical Activation of a Rationally Engineered Signaling EnzymeTargeting EPO and EPO receptor pathways in anemia and dysregulated erythropoiesis.SHP-1: the next checkpoint target for cancer immunotherapy?The Tyrosine Kinome Dictates Breast Cancer Heterogeneity and Therapeutic Responsiveness.A missense methionine mutation augments catalytic activity but reduces thermal stability in two protein tyrosine phosphatases.Covalent inhibition of protein tyrosine phosphatases.Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites.Activation of Engineered Protein Tyrosine Phosphatases with the Biarsenical Compound AsCy3-EDT2.Optimized allosteric inhibition of engineered protein tyrosine phosphatases with an expanded palette of biarsenical small molecules.
P2860
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P2860
Targeting a cryptic allosteric site for selective inhibition of the oncogenic protein tyrosine phosphatase Shp2
description
2015 nî lūn-bûn
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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
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2015年論文
@zh-mo
2015年論文
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2015年论文
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name
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@ast
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@en
type
label
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@ast
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@en
prefLabel
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@ast
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@en
P2860
P356
P1433
P1476
Targeting a cryptic allosteric ...... tein tyrosine phosphatase Shp2
@en
P2093
Anthony C Bishop
P2860
P304
P356
10.1021/BI5013595
P407
P577
2015-01-02T00:00:00Z