Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia - Wikidata - wikimedia - TriplyDB

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

http://www.wikidata.org/entity/Q28298677

about

Function, regulation and pathological roles of the Gab/DOS docking proteins Diversity and functional consequences of germline and somatic PTPN11 mutations in human disease.Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein Small molecule tools for functional interrogation of protein tyrosine phosphatases Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects SHP-2 is a novel target of Abl kinases during cell proliferation.Functional short tandem repeat polymorphism of PTPN11 and susceptibility to hepatocellular carcinoma in Chinese populations Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42 Mutations in PIK3CA are infrequent in neuroblastoma.Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability.Targeting PTPs with small molecule inhibitors in cancer treatment Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation.Src-homology 2 domain-containing tyrosine phosphatase 2 promotes oral cancer invasion and metastasis.Noonan syndrome: clinical aspects and molecular pathogenesis.Functional antagonism between Helicobacter pylori CagA and vacuolating toxin VacA in control of the NFAT signaling pathway in gastric epithelial cells Src homology phosphotyrosyl phosphatase-2 expression is an independent negative prognostic factor in human breast cancer Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112.SHP2E76K mutant promotes lung tumorigenesis in transgenic mice Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome.Therapeutic potential of targeting the oncogenic SHP2 phosphatase.Helicobacter pylori CagA protein polymorphisms and their lack of association with pathogenesis.Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).Association between phosphatase related gene variants and coronary artery disease: case-control study and meta-analysis SHP-2 phosphatase activity is required for PECAM-1-dependent cell motility.SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL.The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis

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Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

http://www.wikidata.org/entity/Q28298677

description

2004 nî lūn-bûn

@nan

2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Activating mutations of the no ...... ult acute myelogenous leukemia

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0008-5472.CAN-04-1923

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Cancer Research

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Activating mutations of the no ...... ult acute myelogenous leukemia

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Andrea Richardson

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Balazs Halmos

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Benjamin G Neel

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David E Fisher

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Frank S David

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Heike Keilhack

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J Guillermo Paez

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Jinyan Du

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John D Minna

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John M Maris

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8816-20

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scholarly article

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2152391

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10.1158/0008-5472.CAN-04-1923

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24

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64

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David J. Sugarbaker

Matthew Meyerson

Alberto Bardelli

Victor Velculescu

Bert Vogelstein

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2004-12-15T00:00:00Z

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15604238

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