Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking.
about
A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD)Pharmacoperones: a new therapeutic approach for diseases caused by misfolded G protein-coupled receptorsEvaluation of traditional medicines for neurodegenerative diseases using Drosophila modelsThe Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder.Crosstalk between the unfolded protein response and NF-κB-mediated inflammation in the progression of chronic kidney diseaseMolecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorderProgress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promiseModulation of toxin stability by 4-phenylbutyric acid and negatively charged phospholipidsA therapeutic chemical chaperone inhibits cholera intoxication and unfolding/translocation of the cholera toxin A1 subunitRestoration of proper trafficking to the cell surface for membrane proteins harboring cysteine mutationsThe effect of chemical chaperones on the assembly and stability of HIV-1 capsid proteinChemical chaperones exceed the chaperone effects of RIC-3 in promoting assembly of functional α7 AChRsPharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital AmaurosisIntegrating the mechanisms of apoptosis induced by endoplasmic reticulum stressThe cellular and molecular bases of leptin and ghrelin resistance in obesity.The improvement effect of L-Lys as a chemical chaperone on STZ-induced diabetic rats, protein structure and function.Stabilization of Nucleotide Binding Domain Dimers Rescues ABCC6 Mutants Associated with Pseudoxanthoma Elasticum.Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.Transcriptional regulation by protein kinase A in Cryptococcus neoformans.Evaluation of N-nonyl-deoxygalactonojirimycin as a pharmacological chaperone for human GM1 gangliosidosis leads to identification of a feline model suitable for testing enzyme enhancement therapy.The quality control theory of aging.Apoptosis-inducing signal sequence mutation in carbonic anhydrase IV identified in patients with the RP17 form of retinitis pigmentosa.Recovery of PEX1-Gly843Asp peroxisome dysfunction by small-molecule compounds.Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death.Reducing the effects of intracellular accumulation of thermolabile collagen II mutants by increasing their thermostability in cell culture conditions.Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in traffickingThe role of endoplasmic reticulum stress in the progression of atherosclerosis.4-Phenylbutyrate attenuates the ER stress response and cyclic AMP accumulation in DYT1 dystonia cell models.Phenylalanine hydroxylase misfolding and pharmacological chaperones.Evidence that proteosome inhibitors and chemical chaperones can rescue the activity of retinol dehydrogenase 12 mutant T49M.Transmembrane helix 1 contributes to substrate translocation and protein stability of bile acid transporter SLC10A2.Therapeutic targeting of misfolding and conformational change in α1-antitrypsin deficiency.Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease.Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways: Potential for Treating Age-related Retinal Degeneration4-PBA prevents pressure overload-induced myocardial hypertrophy and interstitial fibrosis by attenuating endoplasmic reticulum stressThiamine diphosphate binds to intermediates in the assembly of adenovirus fiber knob trimers in Escherichia coliProtein quality control: the who's who, the where's and therapeutic escapes.Glutamate receptors and endoplasmic reticulum quality control: looking beneath the surface.4‑Phenylbutyrate protects rat skin flaps against ischemia‑reperfusion injury and apoptosis by inhibiting endoplasmic reticulum stress.Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress.
P2860
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P2860
Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking.
description
2002 nî lūn-bûn
@nan
2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@ast
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@en
type
label
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@ast
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@en
prefLabel
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@ast
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@en
P2860
P1433
P1476
Chemical chaperones: a pharmac ...... otein folding and trafficking.
@en
P2093
David H Perlmutter
P2860
P304
P356
10.1203/00006450-200212000-00004
P407
P577
2002-12-01T00:00:00Z
P5875
P6179
1033865272