p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
about
SH3 domains of Grb2 adaptor bind to PXpsiPXR motifs within the Sos1 nucleotide exchange factor in a discriminate mannerBivalent binding drives the formation of the Grb2-Gab1 signaling complex in a noncooperative mannerDeregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerSomatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner.Evidence for a p27 tumor suppressive function independent of its role regulating cell proliferation in the prostate.The cyclin-like protein, SPY1, regulates the ERα and ERK1/2 pathways promoting tamoxifen resistance.Assembly of the Sos1-Grb2-Gab1 ternary signaling complex is under allosteric controlRole of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors.p27 suppresses arsenite-induced Hsp27/Hsp70 expression through inhibiting JNK2/c-Jun- and HSF-1-dependent pathways.A novel germline CDKN1B mutation causing multiple endocrine tumors: clinical, genetic and functional characterization.Akt1 sequentially phosphorylates p27kip1 within a conserved but non-canonical regionBinding of the cSH3 domain of Grb2 adaptor to two distinct RXXK motifs within Gab1 docker employs differential mechanisms.Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt-β-catenin signaling.The non-canonical functions of p27(Kip1) in normal and tumor biology.Meet me in the cytoplasm: A role for p27(Kip1) in the control of H-Ras.GEFs in growth factor signaling.P21 and p27: roles in carcinogenesis and drug resistance.Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related statesControl of cell proliferation in atherosclerosis: insights from animal models and human studies.p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms.p27kip1: a new multiple endocrine neoplasia gene?Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma.Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation.Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.p27Kip1 modulates cell migration through the regulation of RhoA activation.Analysis of activated platelet-derived growth factor β receptor and Ras-MAP kinase pathway in equine sarcoid fibroblasts.Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signalingLoss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.A survey and evaluations of histogram-based statistics in alignment-free sequence comparison.MEN4 and CDKN1B mutations: the latest of the MEN syndromes.
P2860
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P2860
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@ast
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@en
type
label
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@ast
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@en
prefLabel
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@ast
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@en
P2093
P2860
P1476
p27Kip1 inhibition of GRB2-SOS formation can regulate Ras activation.
@en
P2093
Elizabeth D Head
Robert J Sheaff
Stephanie J Moeller
P2860
P304
P356
10.1128/MCB.23.11.3735-3752.2003
P407
P577
2003-06-01T00:00:00Z