Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling
about
RAS oncogenes: weaving a tumorigenic webRaft protein clustering alters N-Ras membrane interactions and activation pattern.Restoration of E-cadherin cell-cell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells.Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-ras diffusion and signaling.A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppressionDifferential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signalingp27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling.Ran is a potential therapeutic target for cancer cells with molecular changes associated with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways.Partners in crime: the TGFβ and MAPK pathways in cancer progression.Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotypep27kip1 protein levels reflect a nexus of oncogenic signaling during cell transformation.Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems.Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expressionSrc-mediated caveolin-1 phosphorylation affects the targeting of active Src to specific membrane sites.The residue at position 5 of the N-terminal region of Src and Fyn modulates their myristoylation, palmitoylation, and membrane interactions.An integrated view of cyclin E function and regulationFlipping the switch from g1 to s phase with e3 ubiquitin ligasesDifferential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptorDab2 inhibits the cholesterol-dependent activation of JNK by TGF-βCoated pit-mediated endocytosis of the type I transforming growth factor-β (TGF-β) receptor depends on a di-leucine family signal and is not required for signaling.Differential interference of chlorpromazine with the membrane interactions of oncogenic K-Ras and its effects on cell growth.Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cell line A549.Association of cytoplasmic p27 expression with an unfavorable response to cisplatin-based chemotherapy and poor outcomes in non-small cell lung cancer.Dual effects of Ral-activated pathways on p27 localization and TGF-β signalingFormation of stable homomeric and transient heteromeric bone morphogenetic protein (BMP) receptor complexes regulates Smad protein signaling.Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro.Mitogen-activated protein kinase inhibitors reduce the nuclear accumulation of phosphorylated Smads by inhibiting Imp 7 or Imp 8 in HepG2 cells.
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P2860
Pathway- and expression level-dependent effects of oncogenic N-Ras: p27(Kip1) mislocalization by the Ral-GEF pathway and Erk-mediated interference with Smad signaling
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
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2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
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2005年學術文章
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name
Pathway- and expression level-dependent effects of oncogenic N-Ras: p27
@nl
Pathway- and expression level- ...... terference with Smad signaling
@en
type
label
Pathway- and expression level-dependent effects of oncogenic N-Ras: p27
@nl
Pathway- and expression level- ...... terference with Smad signaling
@en
prefLabel
Pathway- and expression level-dependent effects of oncogenic N-Ras: p27
@nl
Pathway- and expression level- ...... terference with Smad signaling
@en
P2093
P2860
P1476
Pathway- and expression level- ...... terference with Smad signaling
@en
P2093
Ayelet Goldshmid
Marcelo Ehrlich
Shiri Kfir
Yoel Kloog
P2860
P304
P356
10.1128/MCB.25.18.8239-8250.2005
P407
P577
2005-09-01T00:00:00Z