Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage - Wikidata - wikimedia - TriplyDB

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

http://www.wikidata.org/entity/Q35007822

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Matrix rigidity regulates cancer cell growth and cellular phenotype.Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells Tuning cell migration: contractility as an integrator of intracellular signals from multiple cues The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases Capturing relevant extracellular matrices for investigating cell migration A recapitulative three-dimensional model of breast carcinoma requires perfusion for multi-week growth Breaching the Castle Walls: Hyaluronan Depletion as a Therapeutic Approach to Cancer Therapy Recapitulating the Tumor Ecosystem Along the Metastatic Cascade Using 3D Culture Models Mechanochemical regulation of growth cone motility Progenitor Epithelium: Sorting Out Pancreatic Lineages From mechanical force to RhoA activation Insidious changes in stromal matrix fuel cancer progression Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers Tumor cell migration in complex microenvironments Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization.A quantitative comparison of human HT-1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype A synthetic modular approach for modeling the role of the 3D microenvironment in tumor progression Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β Multiparametric classification links tumor microenvironments with tumor cell phenotype A three-dimensional computational model of collagen network mechanics Stromal characteristics may hold the key to mammographic density: the evidence to date Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration.Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression Application of Elastography for the Noninvasive Assessment of Biomechanics in Engineered Biomaterials and Tissues.Tissue stiffness dictates development, homeostasis, and disease progression.A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.Matrix microarchitecture and myosin II determine adhesion in 3D matrices.Integrins and extracellular matrix in mechanotransduction Mechanical phenotype is important for stromal aromatase expression.SRChing for the substrates of Src.The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.Rapid disorganization of mechanically interacting systems of mammary acini.A peptide functionalized poly(ethylene glycol) (PEG) hydrogel for investigating the influence of biochemical and biophysical matrix properties on tumor cell migration.Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber 'cell highways'Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks Dynamic tensile forces drive collective cell migration through three-dimensional extracellular matrices.Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration.Local alignment vectors reveal cancer cell-induced ECM fiber remodeling dynamics.

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P2860

Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage

http://www.wikidata.org/entity/Q35007822

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

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2009年論文

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2009年論文

@zh-hk

2009年論文

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2009年論文

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2009年论文

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name

Matrix density-induced mechano ...... sion through a FAK-ERK linkage

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Matrix density-induced mechano ...... sion through a FAK-ERK linkage

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D R Inman

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K W Eliceiri

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P J Keely

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P P Provenzano

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P2860

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

Rho-stimulated contractility drives the formation of stress fibers and focal adhesions

Regulation of cell motility by mitogen-activated protein kinase

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism

Mammographic density is related to stroma and stromal proteoglycan expression

Greatly increased occurrence of breast cancers in areas of mammographically dense tissue

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

Tensional homeostasis and the malignant phenotype

A gene-expression signature as a predictor of survival in breast cancer

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4326-4343

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10.1038/ONC.2009.299

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2795025

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