Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress - Wikidata - wikimedia - TriplyDB

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

http://www.wikidata.org/entity/Q35008361

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Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy Mechanisms of ferroptosis ROS homeostasis and metabolism: a dangerous liason in cancer cells ROS function in redox signaling and oxidative stress Ferroptosis: an iron-dependent form of nonapoptotic cell death [Ferroptosis, a new form of cell death relevant to the medical treatment of cancer].Ferroptosis: process and function.Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells.Development of small-molecule probes that selectively kill cells induced to express mutant RAS NRF2 and cancer: the good, the bad and the importance of context.Development of synthetic lethality anticancer therapeutics.Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators.Not just gRASping at flaws: finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines.Design and synthesis of N-acylated aza-goniothalamin derivatives and evaluation of their in vitro and in vivo antitumor activity.Tandem Electrocyclic Ring Opening/Radical Cyclization: Application to the Total Synthesis of Cribrostatin 6 Genetic and proteomic approaches to identify cancer drug targets.NCI's provocative questions on cancer: some answers to ignite discussion.Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation.Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle.Killing of Kras-mutant colon cancer cells via Rac-independent actin remodeling by the βGBP cytokine, a physiological PI3K inhibitor therapeutically effective in vivo Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells Oxidants, antioxidants and the current incurability of metastatic cancers.Iron and cancer: recent insights Activation of ERK signaling and induction of colon cancer cell death by piperlongumine.Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.Targeting SOD1 reduces experimental non–small-cell lung cancer KRAS mutant tumor subpopulations can subvert durable responses to personalized cancer treatments Shengmai Formula suppressed over-activated Ras/MAPK pathway in C. elegans by opening mitochondrial permeability transition pore via regulating cyclophilin D.A RAS renaissance: emerging targeted therapies for KRAS-mutated non-small cell lung cancer.Approaches to Ras signaling modulation and treatment of Ras-dependent disorders: a patent review (2007--present).Redox-directed cancer therapeutics: Taurolidine and Piperlongumine as broadly effective antineoplastic agents (review).miR-1298 Inhibits Mutant KRAS-Driven Tumor Growth by Repressing FAK and LAMB3 Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.

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Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress

http://www.wikidata.org/entity/Q35008361

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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Selective killing of K-ras mut ...... e inducers of oxidative stress

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Selective killing of K-ras mut ...... e inducers of oxidative stress

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Selective killing of K-ras mut ...... e inducers of oxidative stress

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Selective killing of K-ras mut ...... e inducers of oxidative stress

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Selective killing of K-ras mut ...... e inducers of oxidative stress

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Proceedings of the National Academy of Sciences of the United States of America

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Selective killing of K-ras mut ...... e inducers of oxidative stress

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Alice T Shaw

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Aravind Subramanian

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Chensi Ouyang

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James Dowdle

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Margaret Magendantz

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Monte M Winslow

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Nicola Tolliday

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Rebecca L Maglathin

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Timothy A Lewis

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Tyler Jacks

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P2860

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles.

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

The role of RAS oncogene in survival of patients with lung cancer: a systematic review of the literature with meta-analysis

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer

Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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