T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. - Wikidata - wikimedia - TriplyDB

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

http://www.wikidata.org/entity/Q35022108

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Current approaches to studying membrane organization Micro- and nanoscale engineering of cell signaling Experimental and theoretical bases for mechanisms of antigen discrimination by T cells Leishmania spp. Proteome Data Sets: A Comprehensive Resource for Vaccine Development to Target Visceral Leishmaniasis Linking form to function: Biophysical aspects of artificial antigen presenting cell design The actin cytoskeleton modulates the activation of iNKT cells by segregating CD1d nanoclusters on antigen-presenting cells.Barcoding T cell calcium response diversity with methods for automated and accurate analysis of cell signals (MAAACS)Myosin IIA modulates T cell receptor transport and CasL phosphorylation during early immunological synapse formation Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-resolution Microscopy Biophysical mechanism of T-cell receptor triggering in a reconstituted system Manipulating the lateral diffusion of surface-anchored EGF demonstrates that receptor clustering modulates phosphorylation levels Single molecule tracking on supported membranes with arrays of optical nanoantennas.The significance of membrane fluidity of feeder cell-derived substrates for maintenance of iPS cell stemness.Molecular Occupancy of Nanodot Arrays.Size-based chromatography of signaling clusters in a living cell membrane Ligand-induced homotypic and heterotypic clustering of apolipoprotein E receptor 2 Meeting report--Visualizing signaling nanoplatforms at a higher spatiotemporal resolution.Molecular kinetics. Ras activation by SOS: allosteric regulation by altered fluctuation dynamics.A quantitative assessment of costimulation and phosphatase activity on microclusters in early T cell signaling.Supported membranes embedded with fixed arrays of gold nanoparticles A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ.Protein Conformational Changes Are Detected and Resolved Site Specifically by Second-Harmonic Generation.E-cadherin junction formation involves an active kinetic nucleation process.How much of virus-specific CD8 T cell reactivity is detected with a peptide pool when compared to individual peptides?Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells.Repeated exposure to trace amounts of woodchuck hepadnavirus induces molecularly evident infection and virus-specific T cell response in the absence of serological infection markers and hepatitis Spatial partitioning improves the reliability of biochemical signaling DNA-mediated assembly of protein heterodimers on membrane surfaces.Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells Signaling clusters in the cell membrane.Characterization and optimization of the glucan particle-based vaccine platform.T cell activation is determined by the number of presented antigens.Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery.Receptor signaling clusters in the immune synapse.New insights into the T cell synapse from single molecule techniques.Structural and biophysical determinants of αβ T-cell antigen recognition.How the TCR balances sensitivity and specificity for the recognition of self and pathogens.The actin-driven spatiotemporal organization of T-cell signaling at the system scale.About supramolecular systems for dynamically probing cells.Organizing MHC Class II Presentation.

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T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters.

http://www.wikidata.org/entity/Q35022108

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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Proceedings of the National Academy of Sciences of the United States of America

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T-cell triggering thresholds a ...... dual T-cell receptor clusters.

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P2093

Boryana N Manz

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Bryan L Jackson

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Jay Groves

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Rebecca S Petit

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P2860

Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

The immunological synapse: a molecular machine controlling T cell activation

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.

T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation.

Cluster size regulates protein sorting in the immunological synapse

Restriction of receptor movement alters cellular response: physical force sensing by EphA2.

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes.

Initiation of TCR signalling revisited.

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Michael L Dustin

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51130825

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