Abrogation of p53 function leads to metastatic transcriptome networks that typify tumor progression in human breast cancer xenografts.
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Aurora-A Kinase as a Promising Therapeutic Target in CancerHistone deacetylase inhibitor trichostatin A enhances the antitumor effect of the oncolytic adenovirus H101 on esophageal squamous cell carcinoma in vitro and in vivo.The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells.Inhibition of Cdk2 kinase activity selectively targets the CD44⁺/CD24⁻/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells.Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasisMultiple breast cancer cell-lines derived from a single tumor differ in their molecular characteristics and tumorigenic potentialObesity, independent of p53 gene dosage, promotes mammary tumor progression and upregulates the p53 regulator microRNA-504.Three interrelated themes in current breast cancer research: gene addiction, phenotypic plasticity, and cancer stem cells.Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathwayInhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells.
P2860
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P2860
Abrogation of p53 function leads to metastatic transcriptome networks that typify tumor progression in human breast cancer xenografts.
description
2010 nî lūn-bûn
@nan
2010 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@ast
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@en
type
label
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@ast
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@en
prefLabel
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@ast
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@en
P2093
P2860
P1476
Abrogation of p53 function lea ...... uman breast cancer xenografts.
@en
P2093
Alexey Leontovich
Angela Amato
Antonino B D'Assoro
Cosima Quatraro
Franca Stivala
James Ingle
Jeffrey L Salisbury
Jennifer R Ayers-Ringler
Kari Hafner
Massimo Libra
P2860
P304
P577
2010-11-01T00:00:00Z