Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells.
about
Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor RadiosensitizationDisruption of clathrin-mediated trafficking causes centrosome overduplication and senescence.Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors.Inhibition of Cdk2 kinase activity selectively targets the CD44⁺/CD24⁻/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells.Link between DNA damage and centriole disengagement/reduplication in untransformed human cells.The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable.Abrogation of p53 function leads to metastatic transcriptome networks that typify tumor progression in human breast cancer xenografts.Valproate inhibits colon cancer growth through cell cycle modification in vivo and in vitroSuppression of centrosome duplication and amplification by deacetylases.P53, cyclin-dependent kinase and abnormal amplification of centrosomes.Genomic instability and colon carcinogenesis: from the perspective of genes.Activated ROCK II by-passes the requirement of the CDK2 activity for centrosome duplication and amplification.CRKL protein overexpression enhances cell proliferation and invasion in pancreatic cancer.The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities.Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7.Cdk2 and Cdk4 regulate the centrosome cycle and are critical mediators of centrosome amplification in p53-null cells.Orc1 controls centriole and centrosome copy number in human cells.The cyclin A centrosomal localization sequence recruits MCM5 and Orc1 to regulate centrosome reduplication.Multiplying madly: deacetylases take charge of centrosome duplication and amplification.
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P2860
Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells.
description
2008 nî lūn-bûn
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2008年の論文
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2008年論文
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2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
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2008年论文
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2008年论文
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name
Roles of cyclins A and E in in ...... tion in p53-compromised cells.
@en
type
label
Roles of cyclins A and E in in ...... tion in p53-compromised cells.
@en
prefLabel
Roles of cyclins A and E in in ...... tion in p53-compromised cells.
@en
P2093
P2860
P356
P1433
P1476
Roles of cyclins A and E in in ...... tion in p53-compromised cells.
@en
P2093
P2860
P2888
P304
P356
10.1038/ONC.2008.161
P407
P577
2008-05-19T00:00:00Z