The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.
about
Dynamics and diverse functions of nuclear pore complex proteinsExchange protein directly activated by cAMP encoded by the mammalian rapgef3 gene: Structure, function and therapeuticsThe nuclear envelope environment and its cancer connections.A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasionThe future of EPAC-targeted therapies: agonism versus antagonismBiochemical and pharmacological characterizations of ESI-09 based EPAC inhibitors: defining the ESI-09 "therapeutic window".The nuclear import of ribosomal proteins is regulated by mTORDNA methylation of alternative promoters directs tissue specific expression of Epac2 isoformsDown-modulation of nucleoporin RanBP2/Nup358 impaired chromosomal alignment and induced mitotic catastrophe.Epac1 interacts with importin β1 and controls neurite outgrowth independently of cAMP and Rap1.Regulation of the inflammatory response of vascular endothelial cells by EPAC1.Analyses of PDE-regulated phosphoproteomes reveal unique and specific cAMP-signaling modules in T cells.Purinergic A2b Receptor Activation by Extracellular Cues Affects Positioning of the Centrosome and Nucleus and Causes Reduced Cell Migration.The role of Epac in the heart.Epac1 links prostaglandin E2 to β-catenin-dependent transcription during epithelial-to-mesenchymal transition.The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal.Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.RAN/RANBP2 polymorphisms and neuroblastoma risk in Chinese children: a three-center case-control study.Epac1 cAMPs out at nuclear pores.Nucleoporin Gene Fusions and Hematopoietic Malignancies
P2860
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P2860
The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The nucleoporin RanBP2 tethers ...... hibits its catalytic activity.
@en
type
label
The nucleoporin RanBP2 tethers ...... hibits its catalytic activity.
@en
prefLabel
The nucleoporin RanBP2 tethers ...... hibits its catalytic activity.
@en
P2093
P2860
P356
P1476
The nucleoporin RanBP2 tethers ...... hibits its catalytic activity.
@en
P2093
Esther Prummel
Holger Rehmann
Johannes L Bos
Lars A T Meijer
Marije G A Rensen
Marjolein J Vliem
Martijn Gloerich
P2860
P304
P356
10.1083/JCB.201011126
P407
P577
2011-06-01T00:00:00Z