Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans - Wikidata - wikimedia - TriplyDB

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

http://www.wikidata.org/entity/Q35050470

about

Pancreatic regulation of glucose homeostasis Multiple roles for the actin cytoskeleton during regulated exocytosis Cyclic AMP dynamics in the pancreatic β-cell Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes Glucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytes cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells.Cyclic AMP sensor EPAC proteins and energy homeostasis.Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S.The future of EPAC-targeted therapies: agonism versus antagonism Coupling of metabolic, second messenger pathways and insulin granule dynamics in pancreatic beta-cells: a computational analysis Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Role of phospholipase Cε in physiological phosphoinositide signaling networks.Pancreatic β-cell response to increased metabolic demand and to pharmacologic secretagogues requires EPAC2A β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminals.Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation.Regulation of the inflammatory response of vascular endothelial cells by EPAC1.New insights concerning the molecular basis for defective glucoregulation in soluble adenylyl cyclase knockout mice The proteins of exocytosis: lessons from the sperm model.U-73122 reduces the cell growth in cultured MG-63 ostesarcoma cell line involving Phosphoinositide-specific Phospholipases C.Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets.Alpha TC1 and Beta-TC-6 genomic profiling uncovers both shared and distinct transcriptional regulatory features with their primary islet counterparts.Epac2A makes a new impact in β-cell biology.PACAP signaling in stress: insights from the chromaffin cell.β-Cell signalling and insulin secretagogues: A path for improved diabetes therapy.CB1 receptors down-regulate a cAMP/Epac2/PLC pathway to silence the nerve terminals of cerebellar granule cells.Spatial control of Epac2 activity by cAMP and Ca2+-mediated activation of Ras in pancreatic β cells.Intracellular cAMP Sensor EPAC: Physiology, Pathophysiology, and Therapeutics Development.Glucotoxicity inhibits cAMP-protein kinase A-potentiated glucose-stimulated insulin secretion in pancreatic β-cells.

P2860

Q26766485-CCA29E83-C6C2-45BD-8E50-37E8DBB6B303 Q26824483-0147A5DF-5516-4D87-A5E7-4193D858795A Q27008275-232FDA79-AE6D-4463-ABB6-8078DBBA1725 Q28067465-F10389D5-E5BB-478E-A926-F10B2CA577C9 Q33609770-2B164931-A7C0-4D71-9592-B0B9FCE0151D Q34148800-656608E8-B03B-4DED-B1E8-BF8F80C9D30F Q34385094-A5228288-E6DE-48F5-9B99-FECC11683093 Q34441486-DB799DBD-5197-4426-9575-99243B1F23EA Q34465923-41C6CA26-0210-40F5-96A0-4288B0770610 Q35630344-3D7D494B-FCC1-43A5-9EBD-2729F7279201 Q35794969-1100C6F3-D1D3-4BC1-8BDF-D78855836233 Q35887430-B76E0B81-3C77-45DB-94E4-E45A45BF85C5 Q37030967-451C0606-CF69-4741-BCC6-CFBC14390702 Q37312262-AF3817D8-0A46-482C-AC7A-98C53C91BA55 Q37625614-46918A06-81CE-4FAA-BF8F-629D29880428 Q37635255-B10537FB-DA3A-46A2-9919-84A9A21D7474 Q37965220-2180FD8C-5F40-4426-AA42-4CB63C67EFDB Q38224884-0A5A5E21-D0C5-4187-A898-2AB74C3169F9 Q38327408-FEBDA606-3033-4F7D-A6C0-ADEEFCEBCE2F Q38619801-695998A3-12BE-4819-92CD-6BAB5D2FA662 Q38747476-D6BF90DF-2F95-4CD5-A6D2-BF9CE4F885B5 Q41696872-197BA6AD-53D5-4C2A-8318-D0D12596E27E Q41850335-9EC3F6C6-6BE2-462C-A453-1C4689844460 Q47609371-549F9C11-F2FE-420C-AAE2-581EFE52058E Q47843111-EAE1D9EA-4417-4A96-A9F3-483D6BFDBC11 Q47905909-85122DD6-6175-4D70-8038-AD43447DA38E Q51027779-BA2943C7-99AE-470F-93C3-468063A471BF Q52656382-89AC496C-3CB7-42C7-AFC1-89420AB2C2E5 Q54341092-CEAABC8A-B4DA-4BD3-83CC-4E7621D5650B

P2860

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

http://www.wikidata.org/entity/Q35050470

description

2011 nî lūn-bûn

@nan

2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@ast

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@en

type

label

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@ast

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@en

prefLabel

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@ast

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@en

P1433

Q35050470-0A0A092A-FC52-4E38-8EF8-9B599D574594

P1476

Q35050470-F45D5561-E7E9-4D2A-AA9F-73C9DF352DAE

P2093

Q35050470-0625C37F-9A2E-4847-9347-E9D9E9EE2C2E

Q35050470-14889A9F-2F99-4AB8-806C-4FF7917DA1EA

Q35050470-1EA00955-44C8-4A80-B4A6-1F7A007277B0

Q35050470-25EDDB5C-66F0-4886-8BAC-DCA4107861EF

Q35050470-4DFCBA8A-5127-49FC-ABB9-F7978348C23D

Q35050470-78CFC803-EE76-4E96-95E7-93665993FF11

Q35050470-8AD57F73-3286-467D-9F34-D3B2903E786E

Q35050470-9CDCDA1C-A5AF-4777-A572-8A4E093B0E23

Q35050470-9E1740CD-A30A-4B1D-B8D9-74D87EDE84AF

Q35050470-D67FD084-3E49-4E06-A5AE-12174579F52A

P2860

Q35050470-008E5442-0FAE-4C58-A15D-E2D88B700E11

Q35050470-04FB24EB-246F-4105-846B-5A147BA69C5A

Q35050470-0A5994D1-5052-4E99-BD94-47B517D798DE

Q35050470-0E355A53-061C-441E-A1D9-EDCB1FA0A2A7

Q35050470-1423D541-6268-4C00-83D9-A3EF67296A95

Q35050470-1AF08656-7982-45DC-86EA-B1FE84AAA8A2

Q35050470-2325FE99-70C7-4B3B-A630-A4B0854A5623

Q35050470-23FAB630-1DD0-4BAC-9DB1-03F26E60E923

Q35050470-255D724A-85C9-4672-9B11-C5F099C5B501

Q35050470-3428B144-9697-4128-A429-1284103664A4

P304

Q35050470-A0D297B8-5987-4B4E-8E68-E18C9F11474E

P31

Q35050470-CC96D766-0077-4E10-9C41-08599D6A97C1

P356

Q35050470-B1C6551E-526E-49B7-8E18-2EC42CCC6F40

P433

Q35050470-814AE6BA-93DC-481F-A769-11C2D4A84EE2

P478

Q35050470-B1572D07-3987-4266-90D9-ABB7AAD58F65

P577

Q35050470-FF34DEAA-F335-4B87-B029-2B53F1044520

P5875

Q35050470-A7855402-D794-4F37-97FB-945A54359091

P698

Q35050470-B6EFA307-3906-4D78-BDD0-DBDC1FB62857

P921

Q35050470-4DB9A6A0-F610-44B2-9AF8-F5A264ECBC0B

P932

Q35050470-C093F376-F503-42B7-8444-18E1E15760D8

P356

P1433

P1476

Phospholipase C-ε links Epac2 ...... rom mouse islets of Langerhans

@en

P2093

Alan V Smrcka

http://www.w3.org/2001/XMLSchema#string

Colin A Leech

http://www.w3.org/2001/XMLSchema#string

Elvira Dzhura

http://www.w3.org/2001/XMLSchema#string

Frank Schwede

http://www.w3.org/2001/XMLSchema#string

George G Holz

http://www.w3.org/2001/XMLSchema#string

Hans-G Genieser

http://www.w3.org/2001/XMLSchema#string

Igor Dzhura

http://www.w3.org/2001/XMLSchema#string

Michael W Roe

http://www.w3.org/2001/XMLSchema#string

Oleg G Chepurny

http://www.w3.org/2001/XMLSchema#string

Xin Xu

http://www.w3.org/2001/XMLSchema#string

P2860

Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells.

Cell physiology of cAMP sensor Epac.

Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells

A new phospholipase-C-calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

P304

121-128

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.4161/ISL.3.3.15507

http://www.w3.org/2001/XMLSchema#string

P433

3

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P577

2011-05-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51037645

http://www.w3.org/2001/XMLSchema#string

P698

21478675

http://www.w3.org/2001/XMLSchema#string

P921

P932

3116928

http://www.w3.org/2001/XMLSchema#string