Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential. - Wikidata - wikimedia - TriplyDB

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

http://www.wikidata.org/entity/Q27863799

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Differentiation of insulin-producing cells from human neural progenitor cells Regulation of glucose homeostasis by GLP-1 GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence Cyclic AMP dynamics in the pancreatic β-cell Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.PKA-dependent potentiation of glucose-stimulated insulin secretion by Epac activator 8-pCPT-2'-O-Me-cAMP-AM in human islets of Langerhans.cAMP mediators of pulsatile insulin secretion from glucose-stimulated single beta-cells.Subthreshold α₂-adrenergic activation counteracts glucagon-like peptide-1 potentiation of glucose-stimulated insulin secretion.Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit.Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells.Effect of renal impairment on the pharmacokinetics of exenatide Bursting and calcium oscillations in pancreatic beta-cells: specific pacemakers for specific mechanisms.GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic beta-cell: implications for the treatment of type 2 diabetes.GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.Local cAMP signaling in disease at a glance Systematic Design of Trypsin Cleavage Site Mutated Exendin4-Cysteine 1, an Orally Bioavailable Glucagon-Like Peptide-1 Receptor Agonist.GPR119 agonists as potential new oral agents for the treatment of type 2 diabetes and obesity.At the centennial of Michaelis and Menten, competing Michaelis-Menten steps explain effect of GLP-1 on blood-brain transfer and metabolism of glucose.Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells.A role of PLC/PKC-dependent pathway in GLP-1-stimulated insulin secretion.The neurotransmitters glycine and GABA stimulate glucagon-like peptide-1 release from the GLUTag cell line.Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 Receptor (GLP1R) binds Glucagon-like peptide-1 GLP-1R:GLP-1 activates G(s)Heterotrimeric G(s) complex dissociates G(s):GTP activates Adenylyl cyclase Activated Adenylyl cyclase synthesizes cyclic AMP PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP Potassium voltage-gated channels close in reponse to PKA ER calcium channels open in response to activated PKA cAMP activates EPAC1 cAMP activates EPAC2 RAP1A exchanges GDP for GTP Systems analysis of GLP-1 receptor signaling in pancreatic β-cells.

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

http://www.wikidata.org/entity/Q27863799

description

2004 nî lūn-bûn

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2004 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

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J.1742-7843.2004.T01-1-PTO950502.X

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Basic and Clinical Pharmacology and Toxicology

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Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.

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Birgitte Brock

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Jesper Gromada

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Ole Schmitz

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A family of cAMP-binding proteins that directly activate Rap1

Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.

Epac-selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca2+-induced Ca2+ release and exocytosis in pancreatic beta-cells.

Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.

Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

Electrophysiology of the pancreatic beta-cell

Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion

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10.1111/J.1742-7843.2004.T01-1-PTO950502.X

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15569269

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