Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. - Wikidata - wikimedia - TriplyDB

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

http://www.wikidata.org/entity/Q35051341

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Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA Oxidative stress, mitochondrial dysfunction, and aging The three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganisms Mitochondrial DNA damage patterns and aging: revising the evidences for humans and mice Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.The role of mitochondrial DNA mutations in mammalian aging Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study Cdc42 and aging of hematopoietic stem cells.Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.Mitochondrial DNA alterations and reduced mitochondrial function in aging Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues.Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.Sequence-based polymorphisms in the mitochondrial D-loop and potential SNP predictors for chronic dialysis Mitochondrial-nuclear epistasis: implications for human aging and longevity.Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection.Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds.The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief.Neutral mitochondrial heteroplasmy and the influence of aging.Mitochondrial longevity pathways Control region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum.Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanisms Bioenergetic origins of complexity and disease.A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cells Mitochondrial DNA sequence variation in single cells from leukemia patients.Amelioration of progressive renal injury by genetic manipulation of Klotho gene.Mechanisms linking mtDNA damage and aging.Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle.Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy Number Mitochondrial dysfunction in aging: Much progress but many unresolved questions.

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P2860

Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.

http://www.wikidata.org/entity/Q35051341

description

2001 nî lūn-bûn

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2001 թվականի մարտին հրատարակված գիտական հոդված

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2001年論文

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Muscle-specific mutations accu ...... control sites for replication.

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Muscle-specific mutations accu ...... control sites for replication.

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Muscle-specific mutations accu ...... control sites for replication.

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Proceedings of the National Academy of Sciences of the United States of America

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Muscle-specific mutations accu ...... control sites for replication.

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P2093

C A Miller

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C Mallidis

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G Attardi

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L Woodhouse

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S Bhasin

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V Askanas

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W K Engel

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Y Bai

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Y Michikawa

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Y Wang

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P2860

Sequence and organization of the human mitochondrial genome

Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication

The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method.

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication.

The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age.

MITOMAP: a human mitochondrial genome database--1998 update.

Length heterogeneity of a conserved displacement-loop sequence in human mitochondrial DNA.

Sequence and properties of the human KB cell and mouse L cell D-loop regions of mitochondrial DNA.

Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA.

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

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4022-4027

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10.1073/PNAS.061013598

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7

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P478

98

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Kevin Yarasheski

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2001-03-13T00:00:00Z

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12059557

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11274426

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31172

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