Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.
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Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNAOxidative stress, mitochondrial dysfunction, and agingThe three genetics (nuclear DNA, mitochondrial DNA, and gut microbiome) of longevity in humans considered as metaorganismsMitochondrial DNA damage patterns and aging: revising the evidences for humans and miceHuman mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAsMitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator miceA mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicineStrikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes.Leveraging existing data sets to generate new insights into Alzheimer's disease biology in specific patient subsets.The role of mitochondrial DNA mutations in mammalian agingAssociation of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.The mtDNA mutator mouse: Dissecting mitochondrial involvement in aging.Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA studyCdc42 and aging of hematopoietic stem cells.Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle.DNA precursor asymmetries in mammalian tissue mitochondria and possible contribution to mutagenesis through reduced replication fidelity.Somatic mitochondrial DNA deletions accumulate to high levels in aging human extraocular muscles.Mitochondrial DNA alterations and reduced mitochondrial function in agingClonally expanded mtDNA point mutations are abundant in individual cells of human tissues.Accumulation of mtDNA variations in human single CD34+ cells from maternally related individuals: effects of aging and family genetic background.Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.Systemic mitochondrial dysfunction and the etiology of Alzheimer's disease and down syndrome dementia.Sequence-based polymorphisms in the mitochondrial D-loop and potential SNP predictors for chronic dialysisMitochondrial-nuclear epistasis: implications for human aging and longevity.Mitochondrial dysfunction in Parkinson's disease: pathogenesis and neuroprotection.Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds.The reductive hotspot hypothesis of mammalian aging: membrane metabolism magnifies mutant mitochondrial mischief.Neutral mitochondrial heteroplasmy and the influence of aging.Mitochondrial longevity pathwaysControl region mtDNA variants: longevity, climatic adaptation, and a forensic conundrum.Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanismsBioenergetic origins of complexity and disease.A review comparing deoxyribonucleoside triphosphate (dNTP) concentrations in the mitochondrial and cytoplasmic compartments of normal and transformed cellsMitochondrial DNA sequence variation in single cells from leukemia patients.Amelioration of progressive renal injury by genetic manipulation of Klotho gene.Mechanisms linking mtDNA damage and aging.Molecular mechanisms for age-associated mitochondrial deficiency in skeletal muscle.Age-Related and Heteroplasmy-Related Variation in Human mtDNA Copy NumberMitochondrial dysfunction in aging: Much progress but many unresolved questions.
P2860
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P2860
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication.
description
2001 nî lūn-bûn
@nan
2001 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի մարտին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Muscle-specific mutations accu ...... control sites for replication.
@ast
Muscle-specific mutations accu ...... control sites for replication.
@en
type
label
Muscle-specific mutations accu ...... control sites for replication.
@ast
Muscle-specific mutations accu ...... control sites for replication.
@en
prefLabel
Muscle-specific mutations accu ...... control sites for replication.
@ast
Muscle-specific mutations accu ...... control sites for replication.
@en
P2093
P2860
P356
P1476
Muscle-specific mutations accu ...... control sites for replication.
@en
P2093
C A Miller
C Mallidis
L Woodhouse
Y Michikawa
P2860
P304
P356
10.1073/PNAS.061013598
P407
P577
2001-03-13T00:00:00Z